π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Anzhela Galstyan, Yogesh Kumar Maurya, Halina Zhylitskaya, Youn Jue Bae, Yi Lin Wu, Michael R. Wasielewski, Tadeusz Lis, Ulrich Dobrindt, Marcin Stępień

Research output: Contribution to journalArticle

Abstract

Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.

Original languageEnglish
Pages (from-to)8262-8266
Number of pages5
JournalChemistry - A European Journal
Volume26
Issue number37
DOIs
Publication statusPublished - Jul 2 2020

Keywords

  • antimicrobial
  • photosensitizers
  • singlet oxygen
  • triplet state
  • π-extended porphyrins

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Galstyan, A., Maurya, Y. K., Zhylitskaya, H., Bae, Y. J., Wu, Y. L., Wasielewski, M. R., Lis, T., Dobrindt, U., & Stępień, M. (2020). π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation. Chemistry - A European Journal, 26(37), 8262-8266. https://doi.org/10.1002/chem.201905372