25th anniversary article: Supramolecular materials for regenerative medicine

Job Boekhoven, Samuel I. Stupp

Research output: Contribution to journalReview article

202 Citations (Scopus)

Abstract

In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function. These requirements make supramolecular materials a great platform to develop regenerative therapies. This review illustrates the emerging science of these materials and their use in a number of applications for regenerative medicine. The emerging science of supramolecular materials in regenerative medicine is reviewed. In supramolecular materials, molecular building blocks are designed to interact with one another via noncovalent interactions in order to create function, which allows the creation of structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function.

Original languageEnglish
Pages (from-to)1642-1659
Number of pages18
JournalAdvanced Materials
Volume26
Issue number11
DOIs
Publication statusPublished - Mar 19 2014

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Keywords

  • healthcare
  • regenerative medicine
  • self-assembly
  • supramolecular materials
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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