A bioactive titanium foam scaffold for bone repair

Erik D. Spoerke, Naomi G. Murray, Huanlong Li, L. Catherine Brinson, David C. Dunand, Samuel I Stupp

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.

Original languageEnglish
Pages (from-to)523-533
Number of pages11
JournalActa Biomaterialia
Volume1
Issue number5
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Titanium
Scaffolds
Foams
Bone
Repair
Tissue
Bone and Bones
Apatites
Apatite
Dental Materials
Finite Element Analysis
Dental prostheses
Dental Implants
Cermets
Hybrid materials
Orthopedics
Ceramics
Bioreactors
Tissue Engineering
Tissue engineering

Keywords

  • Bioreactor
  • Finite element model
  • Hydroxyapatite
  • Organoapatite
  • Osteoblasts
  • Porous titanium
  • Stress-shielding

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

Cite this

Spoerke, E. D., Murray, N. G., Li, H., Brinson, L. C., Dunand, D. C., & Stupp, S. I. (2005). A bioactive titanium foam scaffold for bone repair. Acta Biomaterialia, 1(5), 523-533. https://doi.org/10.1016/j.actbio.2005.04.005

A bioactive titanium foam scaffold for bone repair. / Spoerke, Erik D.; Murray, Naomi G.; Li, Huanlong; Brinson, L. Catherine; Dunand, David C.; Stupp, Samuel I.

In: Acta Biomaterialia, Vol. 1, No. 5, 09.2005, p. 523-533.

Research output: Contribution to journalArticle

Spoerke, ED, Murray, NG, Li, H, Brinson, LC, Dunand, DC & Stupp, SI 2005, 'A bioactive titanium foam scaffold for bone repair', Acta Biomaterialia, vol. 1, no. 5, pp. 523-533. https://doi.org/10.1016/j.actbio.2005.04.005
Spoerke, Erik D. ; Murray, Naomi G. ; Li, Huanlong ; Brinson, L. Catherine ; Dunand, David C. ; Stupp, Samuel I. / A bioactive titanium foam scaffold for bone repair. In: Acta Biomaterialia. 2005 ; Vol. 1, No. 5. pp. 523-533.
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