A bioactive titanium foam scaffold for bone repair

Erik D. Spoerke, Naomi G. Murray, Huanlong Li, L. Catherine Brinson, David C. Dunand, Samuel I. Stupp

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.

Original languageEnglish
Pages (from-to)523-533
Number of pages11
JournalActa Biomaterialia
Volume1
Issue number5
DOIs
Publication statusPublished - Sep 1 2005

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Keywords

  • Bioreactor
  • Finite element model
  • Hydroxyapatite
  • Organoapatite
  • Osteoblasts
  • Porous titanium
  • Stress-shielding

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Spoerke, E. D., Murray, N. G., Li, H., Brinson, L. C., Dunand, D. C., & Stupp, S. I. (2005). A bioactive titanium foam scaffold for bone repair. Acta Biomaterialia, 1(5), 523-533. https://doi.org/10.1016/j.actbio.2005.04.005