A cooperative beads-on-a-string approach to exceptionally stable DNA triplexes

Yan Zheng, Hai Long, George C Schatz, Frederick D. Lewis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A poly(dT) oligomer can serve as the string on which synthetic hairpins possessing poly(dA) and poly(dT) arms connected by a hydrophobic perylene diimide linker are assembled like beads on a string. The synthetic hairpins form head-to-head dimers and trimers, respectively, in the absence of the poly(dT) string and in the presence of a string with inverted polarity at mid-strand. However, they assemble in cooperative head-to-tail fashion on normal poly(dT) oligomers.

Original languageEnglish
Pages (from-to)3830-3832
Number of pages3
JournalChemical Communications
Issue number36
DOIs
Publication statusPublished - 2006

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Poly T
Oligomers
DNA
Perylene
Dimers
triplex DNA

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A cooperative beads-on-a-string approach to exceptionally stable DNA triplexes. / Zheng, Yan; Long, Hai; Schatz, George C; Lewis, Frederick D.

In: Chemical Communications, No. 36, 2006, p. 3830-3832.

Research output: Contribution to journalArticle

Zheng, Yan ; Long, Hai ; Schatz, George C ; Lewis, Frederick D. / A cooperative beads-on-a-string approach to exceptionally stable DNA triplexes. In: Chemical Communications. 2006 ; No. 36. pp. 3830-3832.
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