A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing

Hao Pei, Na Lu, Yanli Wen, Shiping Song, Yan Liu, Hao Yan, Chunhai Fan

Research output: Contribution to journalArticle

327 Citations (Scopus)

Abstract

A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.

Original languageEnglish
Pages (from-to)4754-4758
Number of pages5
JournalAdvanced Materials
Volume22
Issue number42
DOIs
Publication statusPublished - Nov 9 2010

Keywords

  • Aptamer
  • DNA hybridization
  • DNA nanotechnology
  • Electrochemical DNA sensor
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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