A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates

Jaswinder Sharma, Rahul Chhabra, Hao Yan, Yan Liu

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.

Original languageEnglish
Pages (from-to)2140-2142
Number of pages3
JournalChemical Communications
Issue number18
DOIs
Publication statusPublished - 2008

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Oligonucleotides
Gold
Ligands
Nanoparticles
DNA
Metals
Temperature

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates. / Sharma, Jaswinder; Chhabra, Rahul; Yan, Hao; Liu, Yan.

In: Chemical Communications, No. 18, 2008, p. 2140-2142.

Research output: Contribution to journalArticle

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