A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

Qiangbin Wang, Yang Xu, Xiaohang Zhao, Yung Chang, Yan Liu, Lijing Jiang, Jaswinder Sharma, Dong Kyun Seo, Hao Yan

Research output: Contribution to journalArticle

106 Citations (Scopus)


Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

Original languageEnglish
Pages (from-to)6380-6381
Number of pages2
JournalJournal of the American Chemical Society
Issue number20
Publication statusPublished - May 23 2007


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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