A peptide-based material for therapeutic carbon monoxide delivery

John B. Matson, Matthew J. Webber, Vibha K. Tamboli, Benjamin Weber, Samuel I Stupp

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.

Original languageEnglish
Pages (from-to)6689-6692
Number of pages4
JournalSoft Matter
Volume8
Issue number25
DOIs
Publication statusPublished - Jul 7 2012

Fingerprint

Carbon Monoxide
carbon monoxide
peptides
delivery
Peptides
gels
Gels
viability
Amphiphiles
ruthenium
Ruthenium
Nanofibers
preparation
kinetics
Kinetics

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Matson, J. B., Webber, M. J., Tamboli, V. K., Weber, B., & Stupp, S. I. (2012). A peptide-based material for therapeutic carbon monoxide delivery. Soft Matter, 8(25), 6689-6692. https://doi.org/10.1039/c2sm25785h

A peptide-based material for therapeutic carbon monoxide delivery. / Matson, John B.; Webber, Matthew J.; Tamboli, Vibha K.; Weber, Benjamin; Stupp, Samuel I.

In: Soft Matter, Vol. 8, No. 25, 07.07.2012, p. 6689-6692.

Research output: Contribution to journalArticle

Matson, JB, Webber, MJ, Tamboli, VK, Weber, B & Stupp, SI 2012, 'A peptide-based material for therapeutic carbon monoxide delivery', Soft Matter, vol. 8, no. 25, pp. 6689-6692. https://doi.org/10.1039/c2sm25785h
Matson, John B. ; Webber, Matthew J. ; Tamboli, Vibha K. ; Weber, Benjamin ; Stupp, Samuel I. / A peptide-based material for therapeutic carbon monoxide delivery. In: Soft Matter. 2012 ; Vol. 8, No. 25. pp. 6689-6692.
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