A peptide-based material for therapeutic carbon monoxide delivery

John B. Matson, Matthew J. Webber, Vibha K. Tamboli, Benjamin Weber, Samuel I. Stupp

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.

Original languageEnglish
Pages (from-to)6689-6692
Number of pages4
JournalSoft Matter
Volume8
Issue number25
DOIs
Publication statusPublished - Jul 7 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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    Matson, J. B., Webber, M. J., Tamboli, V. K., Weber, B., & Stupp, S. I. (2012). A peptide-based material for therapeutic carbon monoxide delivery. Soft Matter, 8(25), 6689-6692. https://doi.org/10.1039/c2sm25785h