A Review on Surface-Enhanced Raman Scattering

Roberto Pilot, Raffaella Signorini, Christian Durante, Laura Orian, Manjari Bhamidipati, Laura Fabris

Research output: Contribution to journalReview article

Abstract

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

Original languageEnglish
JournalBiosensors
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 17 2019

Fingerprint

Raman Spectrum Analysis
Raman scattering
Biological Science Disciplines
Dermatoglyphics
Statistical Factor Analysis
Language
Amplification
Costs and Cost Analysis
Fabrication
Wavelength
Substrates
Costs
Experiments

Keywords

  • biomedical applications
  • chemical enhancement
  • electromagnetic enhancement
  • enhancement factor
  • excitation wavelength
  • Raman
  • SERS
  • substrates
  • surface enhanced
  • underpotential deposition

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., & Fabris, L. (2019). A Review on Surface-Enhanced Raman Scattering. Biosensors, 9(2). https://doi.org/10.3390/bios9020057

A Review on Surface-Enhanced Raman Scattering. / Pilot, Roberto; Signorini, Raffaella; Durante, Christian; Orian, Laura; Bhamidipati, Manjari; Fabris, Laura.

In: Biosensors, Vol. 9, No. 2, 17.04.2019.

Research output: Contribution to journalReview article

Pilot, R, Signorini, R, Durante, C, Orian, L, Bhamidipati, M & Fabris, L 2019, 'A Review on Surface-Enhanced Raman Scattering', Biosensors, vol. 9, no. 2. https://doi.org/10.3390/bios9020057
Pilot R, Signorini R, Durante C, Orian L, Bhamidipati M, Fabris L. A Review on Surface-Enhanced Raman Scattering. Biosensors. 2019 Apr 17;9(2). https://doi.org/10.3390/bios9020057
Pilot, Roberto ; Signorini, Raffaella ; Durante, Christian ; Orian, Laura ; Bhamidipati, Manjari ; Fabris, Laura. / A Review on Surface-Enhanced Raman Scattering. In: Biosensors. 2019 ; Vol. 9, No. 2.
@article{d4d3506d93164517bc5ced30a01271d7,
title = "A Review on Surface-Enhanced Raman Scattering",
abstract = "Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.",
keywords = "biomedical applications, chemical enhancement, electromagnetic enhancement, enhancement factor, excitation wavelength, Raman, SERS, substrates, surface enhanced, underpotential deposition",
author = "Roberto Pilot and Raffaella Signorini and Christian Durante and Laura Orian and Manjari Bhamidipati and Laura Fabris",
year = "2019",
month = "4",
day = "17",
doi = "10.3390/bios9020057",
language = "English",
volume = "9",
journal = "Biosensors",
issn = "0956-5663",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - A Review on Surface-Enhanced Raman Scattering

AU - Pilot, Roberto

AU - Signorini, Raffaella

AU - Durante, Christian

AU - Orian, Laura

AU - Bhamidipati, Manjari

AU - Fabris, Laura

PY - 2019/4/17

Y1 - 2019/4/17

N2 - Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

AB - Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

KW - biomedical applications

KW - chemical enhancement

KW - electromagnetic enhancement

KW - enhancement factor

KW - excitation wavelength

KW - Raman

KW - SERS

KW - substrates

KW - surface enhanced

KW - underpotential deposition

UR - http://www.scopus.com/inward/record.url?scp=85065091291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065091291&partnerID=8YFLogxK

U2 - 10.3390/bios9020057

DO - 10.3390/bios9020057

M3 - Review article

VL - 9

JO - Biosensors

JF - Biosensors

SN - 0956-5663

IS - 2

ER -