A self-assembly pathway to aligned monodomain gels

Shuming Zhang, Megan A. Greenfield, Alvaro Mata, Liam C. Palmer, Ronit Bitton, Jason R. Mantei, Conrado Aparicio, Monica Olvera De La Cruz, Samuel I Stupp

Research output: Contribution to journalArticle

365 Citations (Scopus)

Abstract

Aggregates of charged amphiphilic molecules have been found to access a structure at elevated temperature that templates alignment of supramolecular fibrils over macroscopic scales. The thermal pathway leads to a lamellar plaque structure with fibrous texture that breaks on cooling into large arrays of aligned nanoscale fibres and forms a strongly birefringent liquid. By manually dragging this liquid crystal from a pipette onto salty media, it is possible to extend this alignment over centimetres in noodle-shaped viscoelastic strings. Using this approach, the solution of supramolecular filaments can be mixed with cells at physiological temperatures to form monodomain gels of aligned cells and filaments. The nature of the self-assembly process and its biocompatibility would allow formation of cellular wires in situ that have any length and customized peptide compositions for use in biological applications.

Original languageEnglish
Pages (from-to)594-601
Number of pages8
JournalNature Materials
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Self assembly
self assembly
filaments
Gels
alignment
pipettes
gels
Liquid Crystals
Lamellar structures
biocompatibility
cells
Biocompatibility
Liquid crystals
Peptides
peptides
strings
templates
textures
Textures
liquid crystals

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Zhang, S., Greenfield, M. A., Mata, A., Palmer, L. C., Bitton, R., Mantei, J. R., ... Stupp, S. I. (2010). A self-assembly pathway to aligned monodomain gels. Nature Materials, 9(7), 594-601. https://doi.org/10.1038/nmat2778

A self-assembly pathway to aligned monodomain gels. / Zhang, Shuming; Greenfield, Megan A.; Mata, Alvaro; Palmer, Liam C.; Bitton, Ronit; Mantei, Jason R.; Aparicio, Conrado; De La Cruz, Monica Olvera; Stupp, Samuel I.

In: Nature Materials, Vol. 9, No. 7, 07.2010, p. 594-601.

Research output: Contribution to journalArticle

Zhang, S, Greenfield, MA, Mata, A, Palmer, LC, Bitton, R, Mantei, JR, Aparicio, C, De La Cruz, MO & Stupp, SI 2010, 'A self-assembly pathway to aligned monodomain gels', Nature Materials, vol. 9, no. 7, pp. 594-601. https://doi.org/10.1038/nmat2778
Zhang S, Greenfield MA, Mata A, Palmer LC, Bitton R, Mantei JR et al. A self-assembly pathway to aligned monodomain gels. Nature Materials. 2010 Jul;9(7):594-601. https://doi.org/10.1038/nmat2778
Zhang, Shuming ; Greenfield, Megan A. ; Mata, Alvaro ; Palmer, Liam C. ; Bitton, Ronit ; Mantei, Jason R. ; Aparicio, Conrado ; De La Cruz, Monica Olvera ; Stupp, Samuel I. / A self-assembly pathway to aligned monodomain gels. In: Nature Materials. 2010 ; Vol. 9, No. 7. pp. 594-601.
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