A tripodal peptidic titanium phosphonate as a homochiral porous solid medium for the heterogeneous enantioselective hydration of epoxides

Anat Milo, Ronny Neumann

Research output: Contribution to journalArticle

10 Citations (Scopus)


A porous, homochiral titanium-phosphonate material based on a tripodal peptide scaffold was used as a heterogeneous reaction medium for the enantioselective hydration (>99%) of styrene oxide. This titanium-phosphonate material, which was shown to contain confined chiral spaces, was prepared by polymerization of L-leucine onto a tris(2-aminoethyl)amine initiator, followed by capping with phosphonate groups and completed by non-aqueous condensation with titanium isopropoxide. Circular dichroism confirmed that the peptide tethers yielded a secondary structure. X-ray powder diffraction and transmission electron microscopy supported by a semi-empirical model showed the likely formation of a porous, lamellar material that was quantified by nitrogen adsorption.

Original languageEnglish
Pages (from-to)2159-2165
Number of pages7
JournalAdvanced Synthesis and Catalysis
Issue number13
Publication statusPublished - Sep 10 2010



  • Catalyst design
  • Enantioselectivity
  • Hydrolysis
  • Organic-inorganic composites
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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