A unidirectional DNA walker that moves autonomously along a track

Peng Yin, Hao Yan, Xiaoju G. Daniell, Andrew J. Turberfield, John H. Reif

Research output: Contribution to journalArticle

322 Citations (Scopus)

Abstract

There's no turning back for an autonomous DNA walker that moves along a self-assembled track, driven by the hydrolysis of ATP. The track contains three anchorages (A, B, C) at which the walker (*), a six-nucleotide DNA fragment, can be bound (see figure). The motion of the walker is unidirectional. At each step it is ligated to the next anchorage, then cut from the previous one by a restriction endonuclease.

Original languageEnglish
Pages (from-to)4906-4911
Number of pages6
JournalAngewandte Chemie - International Edition
Volume43
Issue number37
DOIs
Publication statusPublished - Sep 20 2004

Keywords

  • DNA
  • Molecular devices
  • Nanorobotics
  • Nanostructures
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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