TY - JOUR
T1 - Acceptorless Dehydrogenative Coupling Using Ammonia
T2 - Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium
AU - Daw, Prosenjit
AU - Ben-David, Yehoshoa
AU - Milstein, David
N1 - Publisher Copyright:
© 2018 American Chemical Society.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/9/26
Y1 - 2018/9/26
N2 - The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.
AB - The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.
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U2 - 10.1021/jacs.8b08385
DO - 10.1021/jacs.8b08385
M3 - Article
C2 - 30205675
AN - SCOPUS:85053690008
VL - 140
SP - 11931
EP - 11934
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 38
ER -