Abstract
The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.
| Original language | English |
|---|---|
| Pages (from-to) | 11931-11934 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 140 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - Sep 26 2018 |
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ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Acceptorless Dehydrogenative Coupling Using Ammonia : Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium. / Daw, Prosenjit; Ben-David, Yehoshoa; Milstein, David.
In: Journal of the American Chemical Society, Vol. 140, No. 38, 26.09.2018, p. 11931-11934.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acceptorless Dehydrogenative Coupling Using Ammonia
T2 - Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium
AU - Daw, Prosenjit
AU - Ben-David, Yehoshoa
AU - Milstein, David
PY - 2018/9/26
Y1 - 2018/9/26
N2 - The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.
AB - The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.
UR - http://www.scopus.com/inward/record.url?scp=85053690008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053690008&partnerID=8YFLogxK
U2 - 10.1021/jacs.8b08385
DO - 10.1021/jacs.8b08385
M3 - Article
VL - 140
SP - 11931
EP - 11934
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 38
ER -