Acceptorless Dehydrogenative Coupling Using Ammonia

Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium

Prosenjit Daw, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.

Original languageEnglish
Pages (from-to)11931-11934
Number of pages4
JournalJournal of the American Chemical Society
Volume140
Issue number38
DOIs
Publication statusPublished - Sep 26 2018

Fingerprint

Acridines
Ruthenium
Ammonia
Pyrazines
Pyrroles
Nitrogen
Alcohols
Ligands
Derivatives
Catalysts

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Acceptorless Dehydrogenative Coupling Using Ammonia : Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium. / Daw, Prosenjit; Ben-David, Yehoshoa; Milstein, David.

In: Journal of the American Chemical Society, Vol. 140, No. 38, 26.09.2018, p. 11931-11934.

Research output: Contribution to journalArticle

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