Active hydrogenation catalyst with a structured, peptide-based outer-coordination sphere

Avijita Jain, Garry W. Buchko, Matthew L. Reback, Molly O'Hagan, Bojana Ginovska-Pangovska, John C. Linehan, Wendy J. Shaw

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H 2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 ± 50 turnovers/Rh/h at 294 K. This peptidebased catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.

Original languageEnglish
Pages (from-to)2114-2118
Number of pages5
JournalACS Catalysis
Issue number10
Publication statusPublished - Oct 5 2012


  • Artificial enzyme
  • Bioinspired catalyst
  • Hydrogenation catalysis
  • Outer-coordination sphere
  • Peptide catalyst

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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