Abstract
The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H 2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 ± 50 turnovers/Rh/h at 294 K. This peptidebased catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.
| Original language | English |
|---|---|
| Pages (from-to) | 2114-2118 |
| Number of pages | 5 |
| Journal | ACS Catalysis |
| Volume | 2 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 5 2012 |
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Keywords
- Artificial enzyme
- Bioinspired catalyst
- Hydrogenation catalysis
- Outer-coordination sphere
- Peptide catalyst
ASJC Scopus subject areas
- Catalysis
Cite this
Active hydrogenation catalyst with a structured, peptide-based outer-coordination sphere. / Jain, Avijita; Buchko, Garry W.; Reback, Matthew L.; O'Hagan, Molly; Ginovska-Pangovska, Bojana; Linehan, John; Shaw, Wendy J.
In: ACS Catalysis, Vol. 2, No. 10, 05.10.2012, p. 2114-2118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Active hydrogenation catalyst with a structured, peptide-based outer-coordination sphere
AU - Jain, Avijita
AU - Buchko, Garry W.
AU - Reback, Matthew L.
AU - O'Hagan, Molly
AU - Ginovska-Pangovska, Bojana
AU - Linehan, John
AU - Shaw, Wendy J.
PY - 2012/10/5
Y1 - 2012/10/5
N2 - The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H 2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 ± 50 turnovers/Rh/h at 294 K. This peptidebased catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.
AB - The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H 2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 ± 50 turnovers/Rh/h at 294 K. This peptidebased catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.
KW - Artificial enzyme
KW - Bioinspired catalyst
KW - Hydrogenation catalysis
KW - Outer-coordination sphere
KW - Peptide catalyst
UR - http://www.scopus.com/inward/record.url?scp=84868575010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868575010&partnerID=8YFLogxK
U2 - 10.1021/cs3004177
DO - 10.1021/cs3004177
M3 - Article
AN - SCOPUS:84868575010
VL - 2
SP - 2114
EP - 2118
JO - ACS Catalysis
JF - ACS Catalysis
SN - 2155-5435
IS - 10
ER -