Abstract
The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H 2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 ± 50 turnovers/Rh/h at 294 K. This peptidebased catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.
Original language | English |
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Pages (from-to) | 2114-2118 |
Number of pages | 5 |
Journal | ACS Catalysis |
Volume | 2 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 5 2012 |
Keywords
- Artificial enzyme
- Bioinspired catalyst
- Hydrogenation catalysis
- Outer-coordination sphere
- Peptide catalyst
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)