Addressable molecular tweezers for DNA-templated coupling reactions

Rahul Chhabra, Jaswinder Sharma, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Here we report the construction of fully addressable DNA-based molecular tweezers to actuate coupling reactions in a programmable fashion. Three tweezers, each bearing two coupling reactants, are self-assembled on a linear DNA track. A fourth tweezer floating freely in solution can be brought to any one of the tweezers and close them by the addition of a unique pair of "fuel" DNA strands. The coupling reactions happen when the tweezers are closed, and this can be controlled sequentially from one tweezer to another. A molecular device of this kind would not only enable programmable chemical reactions but also allow distance-dependent control of biomolecular interactions.

Original languageEnglish
Pages (from-to)978-983
Number of pages6
JournalNano Letters
Volume6
Issue number5
DOIs
Publication statusPublished - May 2006

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DNA
deoxyribonucleic acid
Bearings (structural)
strands
floating
Chemical reactions
chemical reactions
interactions

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)
  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Mechanical Engineering

Cite this

Addressable molecular tweezers for DNA-templated coupling reactions. / Chhabra, Rahul; Sharma, Jaswinder; Liu, Yan; Yan, Hao.

In: Nano Letters, Vol. 6, No. 5, 05.2006, p. 978-983.

Research output: Contribution to journalArticle

Chhabra, Rahul ; Sharma, Jaswinder ; Liu, Yan ; Yan, Hao. / Addressable molecular tweezers for DNA-templated coupling reactions. In: Nano Letters. 2006 ; Vol. 6, No. 5. pp. 978-983.
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