Adjusting the Metrics of 1-D Helical Gold Nanoparticle Superstructures Using Multivalent Peptide Conjugates

Andrea D. Merg, Joseph Slocik, Martin G. Blaber, George C Schatz, Rajesh Naik, Nathaniel L. Rosi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The properties of nanoparticle superstructures depend on many factors, including the structural metrics of the nanoparticle superstructure (particle diameter, interparticle distances, etc.). Here, we introduce a family of gold-binding peptide conjugate molecules that can direct nanoparticle assembly, and we describe how these molecules can be systematically modified to adjust the structural metrics of linear double-helical nanoparticle superstructures. Twelve new peptide conjugates are prepared via linking a gold-binding peptide, AYSSGAPPMPPF (PEPAu), to a hydrophobic aliphatic tail. The peptide conjugates have 1, 2, or 3 PEPAu headgroups and a C12, C14, C16, or C18 aliphatic tail. The soft assembly of these peptide conjugates was studied using transmission electron microscopy (TEM), atomic force microscopy (AFM), and infrared (IR) spectroscopy. Several peptide conjugates assemble into 1-D twisted fibers having measurable structural parameters such as fiber width, thickness, and pitch that can be systematically varied by adjusting the aliphatic tail length and number of peptide headgroups. The linear soft assemblies serve as structural scaffolds for arranging gold nanoparticles into double-helical superstructures, which are examined via TEM. The pitch and interparticle distances of the gold nanoparticle double helices correspond to the underlying metrics of the peptide conjugate soft assemblies, illustrating that designed peptide conjugate molecules can be used to not only direct the assembly of gold nanoparticles but also control the metrics of the assembled structure. (Figure Presented).

Original languageEnglish
Pages (from-to)9492-9501
Number of pages10
JournalLangmuir
Volume31
Issue number34
DOIs
Publication statusPublished - Sep 1 2015

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Gold
Peptides
peptides
adjusting
gold
Nanoparticles
nanoparticles
assembly
assemblies
Molecules
Transmission electron microscopy
molecules
transmission electron microscopy
fibers
Fibers
Scaffolds
helices
Infrared spectroscopy
Atomic force microscopy
infrared spectroscopy

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Adjusting the Metrics of 1-D Helical Gold Nanoparticle Superstructures Using Multivalent Peptide Conjugates. / Merg, Andrea D.; Slocik, Joseph; Blaber, Martin G.; Schatz, George C; Naik, Rajesh; Rosi, Nathaniel L.

In: Langmuir, Vol. 31, No. 34, 01.09.2015, p. 9492-9501.

Research output: Contribution to journalArticle

Merg, Andrea D. ; Slocik, Joseph ; Blaber, Martin G. ; Schatz, George C ; Naik, Rajesh ; Rosi, Nathaniel L. / Adjusting the Metrics of 1-D Helical Gold Nanoparticle Superstructures Using Multivalent Peptide Conjugates. In: Langmuir. 2015 ; Vol. 31, No. 34. pp. 9492-9501.
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