Abstract
Elucidating the structural information of nanoscale materials in their solvent-exposed state is crucial, as a result, cryogenic transmission electron microscopy (cryo-TEM) has become an increasingly popular technique in the materials science, chemistry, and biology communities. Cryo-TEM provides a method to directly visualize the specimen structure in a solution-state through a thin film of vitrified solvent. This technique complements X-ray, neutron, and light scattering methods that probe the statistical average of all species present; furthermore, cryo-TEM can be used to observe changes in structure over time. In the area of self-assembly, this tool has been particularly powerful for the characterization of natural and synthetic small molecule assemblies, as well as hybrid organic-inorganic composites. In this review, we discuss recent advances in cryogenic TEM in the context of self-assembling systems with emphasis on characterization of transitions observed in response to external stimuli.
| Original language | English |
|---|---|
| Pages (from-to) | 350-359 |
| Number of pages | 10 |
| Journal | Current Opinion in Colloid and Interface Science |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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Keywords
- Amyloid fibril assembly
- Block copolymer assembly
- Cryogenic transmission electron microscopy
- Hybrid materials
- Peptide amphiphile
- Self-assembly
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Colloid and Surface Chemistry
- Surfaces and Interfaces
Cite this
Advances in cryogenic transmission electron microscopy for the characterization of dynamic self-assembling nanostructures. / Newcomb, Christina J.; Moyer, Tyson J.; Lee, Sungsoo S.; Stupp, Samuel I.
In: Current Opinion in Colloid and Interface Science, Vol. 17, No. 6, 12.2012, p. 350-359.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Advances in cryogenic transmission electron microscopy for the characterization of dynamic self-assembling nanostructures
AU - Newcomb, Christina J.
AU - Moyer, Tyson J.
AU - Lee, Sungsoo S.
AU - Stupp, Samuel I
PY - 2012/12
Y1 - 2012/12
N2 - Elucidating the structural information of nanoscale materials in their solvent-exposed state is crucial, as a result, cryogenic transmission electron microscopy (cryo-TEM) has become an increasingly popular technique in the materials science, chemistry, and biology communities. Cryo-TEM provides a method to directly visualize the specimen structure in a solution-state through a thin film of vitrified solvent. This technique complements X-ray, neutron, and light scattering methods that probe the statistical average of all species present; furthermore, cryo-TEM can be used to observe changes in structure over time. In the area of self-assembly, this tool has been particularly powerful for the characterization of natural and synthetic small molecule assemblies, as well as hybrid organic-inorganic composites. In this review, we discuss recent advances in cryogenic TEM in the context of self-assembling systems with emphasis on characterization of transitions observed in response to external stimuli.
AB - Elucidating the structural information of nanoscale materials in their solvent-exposed state is crucial, as a result, cryogenic transmission electron microscopy (cryo-TEM) has become an increasingly popular technique in the materials science, chemistry, and biology communities. Cryo-TEM provides a method to directly visualize the specimen structure in a solution-state through a thin film of vitrified solvent. This technique complements X-ray, neutron, and light scattering methods that probe the statistical average of all species present; furthermore, cryo-TEM can be used to observe changes in structure over time. In the area of self-assembly, this tool has been particularly powerful for the characterization of natural and synthetic small molecule assemblies, as well as hybrid organic-inorganic composites. In this review, we discuss recent advances in cryogenic TEM in the context of self-assembling systems with emphasis on characterization of transitions observed in response to external stimuli.
KW - Amyloid fibril assembly
KW - Block copolymer assembly
KW - Cryogenic transmission electron microscopy
KW - Hybrid materials
KW - Peptide amphiphile
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=84870672742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870672742&partnerID=8YFLogxK
U2 - 10.1016/j.cocis.2012.09.004
DO - 10.1016/j.cocis.2012.09.004
M3 - Article
AN - SCOPUS:84870672742
VL - 17
SP - 350
EP - 359
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
SN - 1359-0294
IS - 6
ER -