Aerobic oxidation of primary aliphatic alcohols to aldehydes catalyzed by a palladium(II) polyoxometalate catalyst

Delina Barats, Ronny Neumann

Research output: Contribution to journalArticle

45 Citations (Scopus)


A hexadecyltrimethylammonium salt of a "sandwich" type polyoxometalate has been used as a ligand to attach a palladium(II) center. This Pd-POM compound was an active catalyst for the fast aerobic oxidation of alcohols. The unique property of this catalyst is its significant preference for the oxidation of primary versus secondary aliphatic alcohols. Since no kinetic isotope effect was observed for the dehydrogenation step, this may be the result of the intrinsically higher probability for oxidation of primary alcohols attenuated by steric factors as borne out by the higher reactivity of 1-octanol versus 2-ethyl-1-hexanol. The reaction is highly selective to aldehyde with little formation of carboxylic acid; autooxidation is inhibited. No base is required to activate the alcohol. The fast reactions appear to be related to the electron-acceptor nature of the polyoxometalate ligand that may also facilitate alcohol dehydrogenation in the absence of base.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalAdvanced Synthesis and Catalysis
Issue number2-3
Publication statusPublished - Feb 15 2010



  • Alcohols
  • Oxidation
  • Oxygen
  • Palladium
  • Polyoxometalates

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this