Aerosol-jet-printed graphene electrochemical histamine sensors for food safety monitoring

Kshama Parate, Cícero C. Pola, Sonal V. Rangnekar, Deyny L. Mendivelso-Perez, Emily A. Smith, Mark C. Hersam, Carmen L. Gomes, Jonathan C. Claussen

Research output: Contribution to journalArticle

Abstract

Carbon nanomaterials such as graphene exhibit unique material properties including high electrical conductivity, surface area, and biocompatibility that have the potential to significantly improve the performance of electrochemical sensors. Since in-field electrochemical sensors are typically disposable, they require materials that are amenable to low-cost, high-throughput, and scalable manufacturing. Conventional graphene devices based on low-yield chemical vapor deposition techniques are too expensive for such applications, while low-cost alternatives such as screen and inkjet printing do not possess sufficient control over electrode geometry to achieve favorable electrochemical sensor performance. In this work, aerosol jet printing (AJP) is used to create high-resolution (∼40 μm line width) interdigitated electrodes (IDEs) on flexible substrates, which are then converted into histamine sensors by covalently linking monoclonal antibodies to oxygen moieties created on the graphene surface through a CO2 thermal annealing process. The resulting electrochemical sensors exhibit a wide histamine sensing range of 6.25-200 ppm (56.25 μM-1.8 mM) and a low detection limit of 3.41 ppm (30.7 μM) within actual tuna broth samples. These sensor metrics are significant since histamine levels over 50 ppm in fish induce adverse health effects including severe allergic reactions (e.g. Scombroid food poisoning). Beyond the histamine case study presented here, the AJP and functionalization process can likely be generalized to a diverse range of sensing applications including environmental toxin detection, foodborne pathogen detection, wearable health monitoring, and health diagnostics.

Original languageEnglish
Article number034002
Journal2D Materials
Volume7
Issue number3
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Aerosol jet printing
  • Electrochemical impedance spectroscopy
  • Food safety
  • Graphene
  • Immunosensor
  • Interdigitated electrode

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Parate, K., Pola, C. C., Rangnekar, S. V., Mendivelso-Perez, D. L., Smith, E. A., Hersam, M. C., Gomes, C. L., & Claussen, J. C. (2020). Aerosol-jet-printed graphene electrochemical histamine sensors for food safety monitoring. 2D Materials, 7(3), [034002]. https://doi.org/10.1088/2053-1583/ab8919