Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

Job Boekhoven, R. Helen Zha, Faifan Tantakitti, Ellen Zhuang, Roya Zandi, Christina J. Newcomb, Samuel I Stupp

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

Original languageEnglish
Pages (from-to)8753-8756
Number of pages4
JournalRSC Advances
Volume5
Issue number12
DOIs
Publication statusPublished - 2015

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Amphiphiles
Alginate
Peptides
Cytotoxicity
Nanofibers
Folic Acid
Pharmaceutical Preparations
Doxorubicin
Self assembly
Cells
Geometry
alginic acid
Targeted drug delivery
Drug Delivery Systems

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Boekhoven, J., Zha, R. H., Tantakitti, F., Zhuang, E., Zandi, R., Newcomb, C. J., & Stupp, S. I. (2015). Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. RSC Advances, 5(12), 8753-8756. https://doi.org/10.1039/c4ra16593d

Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. / Boekhoven, Job; Zha, R. Helen; Tantakitti, Faifan; Zhuang, Ellen; Zandi, Roya; Newcomb, Christina J.; Stupp, Samuel I.

In: RSC Advances, Vol. 5, No. 12, 2015, p. 8753-8756.

Research output: Contribution to journalArticle

Boekhoven, J, Zha, RH, Tantakitti, F, Zhuang, E, Zandi, R, Newcomb, CJ & Stupp, SI 2015, 'Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system', RSC Advances, vol. 5, no. 12, pp. 8753-8756. https://doi.org/10.1039/c4ra16593d
Boekhoven J, Zha RH, Tantakitti F, Zhuang E, Zandi R, Newcomb CJ et al. Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. RSC Advances. 2015;5(12):8753-8756. https://doi.org/10.1039/c4ra16593d
Boekhoven, Job ; Zha, R. Helen ; Tantakitti, Faifan ; Zhuang, Ellen ; Zandi, Roya ; Newcomb, Christina J. ; Stupp, Samuel I. / Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. In: RSC Advances. 2015 ; Vol. 5, No. 12. pp. 8753-8756.
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