Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

Job Boekhoven, R. Helen Zha, Faifan Tantakitti, Ellen Zhuang, Roya Zandi, Christina J. Newcomb, Samuel I. Stupp

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47 Citations (Scopus)

Abstract

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

Original languageEnglish
Pages (from-to)8753-8756
Number of pages4
JournalRSC Advances
Volume5
Issue number12
DOIs
Publication statusPublished - 2015

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Boekhoven, J., Zha, R. H., Tantakitti, F., Zhuang, E., Zandi, R., Newcomb, C. J., & Stupp, S. I. (2015). Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system. RSC Advances, 5(12), 8753-8756. https://doi.org/10.1039/c4ra16593d