Abstract
The reactions of 2-alkoxy-1,3,2-dioxaphospholane 2-oxide with various nucleophiles were studied both experimentally and theoretically. These studies show that 5-membered ring phosphate triesters act as ambident electrophiles: hard and bulky nucleophiles attack at the phosphorus while soft nucleophiles attack at the ring carbon.
Original language | English |
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Pages (from-to) | 420-424 |
Number of pages | 5 |
Journal | Phosphorus, Sulfur and Silicon and the Related Elements |
Volume | 183 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Feb 1 2008 |
Keywords
- 2-Alkoxy-1,3,2-dioxaphospholane 2-oxide
- Electrophilicity
- Hard and soft nucleophiles
- Steric bulk
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Inorganic Chemistry