Antineoplastic agents. 55. Isolation and structure of multigilin and multistatin

George R. Pettit, Cherry L. Herald, John Devens Gust, Delbert L. Herald, Lawrence D. Vanell

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Abstract

Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (1c) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (1c), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (1b), fastigilin C (2a), and multiradiatin (2c).

Original languageEnglish
Pages (from-to)1092-1095
Number of pages4
JournalJournal of Organic Chemistry
Volume43
Issue number6
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Organic Chemistry

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    Pettit, G. R., Herald, C. L., Gust, J. D., Herald, D. L., & Vanell, L. D. (1978). Antineoplastic agents. 55. Isolation and structure of multigilin and multistatin. Journal of Organic Chemistry, 43(6), 1092-1095.