Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (1c) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (1c), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (1b), fastigilin C (2a), and multiradiatin (2c).
|Number of pages||4|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Organic Chemistry