Antitags: Nanostructured tools for developing SERS-based ELISA analogs

Nekane Guarrotxena, Bin Liu, Laura Fabris, Guillermo C. Bazan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Antitags are reported. These materials bring together two or more metallic nanoparticles by using a dithiolated organic molecule and contain antibodies on the surface to function as antigen-specific recognition elements. The linker position leads to a behavior characteristic of surface enhanced Raman spectroscopy (SERS). In conjunction with a surface containing capture antibody, antitags can be used to detect antigens with sensitivities approaching those of the widely used enzyme linked immunosorbent assay (ELISA).

Original languageEnglish
Pages (from-to)4954-4958
Number of pages5
JournalAdvanced Materials
Volume22
Issue number44
DOIs
Publication statusPublished - Nov 24 2010

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Keywords

  • biosensors
  • nanoparticles
  • nanostructures
  • silver

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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