Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy

Laura Fabris, Martin Schierhorn, Martin Moskovits, Guillermo C. Bazan

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Silver-nanoparticle dimers held together by a Raman reporter, capped with DNA aptamers and stabilized by polyethylene glycol chains, can be used to develop a multiplexed heterogeneous bioassay for protein detection with high sensitivity and selectivity.

Original languageEnglish
Pages (from-to)1550-1557
Number of pages8
JournalSmall
Volume6
Issue number14
DOIs
Publication statusPublished - Jul 19 2010

Fingerprint

Nucleotide Aptamers
Raman Spectrum Analysis
Bioassay
Silver
Biological Assay
Dimers
Nanoparticles
Polyethylene glycols
Raman spectroscopy
Assays
Membrane Proteins
DNA
Proteins

Keywords

  • Aptamers
  • Bioassays
  • Nanoparticles
  • Proteins
  • Raman spectroscopy

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy. / Fabris, Laura; Schierhorn, Martin; Moskovits, Martin; Bazan, Guillermo C.

In: Small, Vol. 6, No. 14, 19.07.2010, p. 1550-1557.

Research output: Contribution to journalArticle

Fabris, Laura ; Schierhorn, Martin ; Moskovits, Martin ; Bazan, Guillermo C. / Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy. In: Small. 2010 ; Vol. 6, No. 14. pp. 1550-1557.
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