Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces

Randal C. Claussen, Bryan M. Rabatic, Samuel I Stupp

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Unsymmetric peptide bolaamphiphiles that incorporate (L-glutamyl)3glycine at one terminus and either tetraethylene glycol or aspartic acid at the other were found to form hydrogels at low wt %, presumably by self-assembling into nanofibers presenting (L-glutamyl)3glycine at their surfaces and burying the second headgroup at their cores. Transmission electron microscopy measurements on 1 wt % gels negatively stained with phosphotungstic acid and positively stained with uranyl acetate show one-dimensional objects with diameters of 5 nm and lengths in excess of 1 μm. Circular dichroism and solid-state FTIR spectra indicate the adoption of β-sheet structure within the nanofibers.

Original languageEnglish
Pages (from-to)12680-12681
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number42
DOIs
Publication statusPublished - Oct 22 2003

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Nanofibers
Self assembly
Peptides
Phosphotungstic Acid
Hydrogels
Glycols
Acids
Dichroism
Fourier Transform Infrared Spectroscopy
Circular Dichroism
Transmission Electron Microscopy
Aspartic Acid
Gels
Transmission electron microscopy
bolaamphiphile
uranyl acetate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces. / Claussen, Randal C.; Rabatic, Bryan M.; Stupp, Samuel I.

In: Journal of the American Chemical Society, Vol. 125, No. 42, 22.10.2003, p. 12680-12681.

Research output: Contribution to journalArticle

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