Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces

Randal C. Claussen, Bryan M. Rabatic, Samuel I. Stupp

Research output: Contribution to journalArticle

157 Citations (Scopus)


Unsymmetric peptide bolaamphiphiles that incorporate (L-glutamyl)3glycine at one terminus and either tetraethylene glycol or aspartic acid at the other were found to form hydrogels at low wt %, presumably by self-assembling into nanofibers presenting (L-glutamyl)3glycine at their surfaces and burying the second headgroup at their cores. Transmission electron microscopy measurements on 1 wt % gels negatively stained with phosphotungstic acid and positively stained with uranyl acetate show one-dimensional objects with diameters of 5 nm and lengths in excess of 1 μm. Circular dichroism and solid-state FTIR spectra indicate the adoption of β-sheet structure within the nanofibers.

Original languageEnglish
Pages (from-to)12680-12681
Number of pages2
JournalJournal of the American Chemical Society
Issue number42
Publication statusPublished - Oct 22 2003


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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