Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki; Sy Tsong Dean Chueng; Perry T. Yin; Rajesh Kappera; Manish Chhowalla; Ki Bum Lee

doi:10.1002/adma.201302219

Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki, Sy Tsong Dean Chueng, Perry T. Yin, Rajesh Kappera, Manish Chhowalla, Ki Bum Lee

Rutgers University

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Original language	English
Pages (from-to)	5477-5482
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	38
DOIs	https://doi.org/10.1002/adma.201302219
Publication status	Published - Oct 11 2013

Keywords

axonal alignment
graphene-coated nanostructures
neural stem cells
stem cell differentiation

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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AU - Yin, Perry T.

AU - Kappera, Rajesh

AU - Chhowalla, Manish

AU - Lee, Ki Bum

PY - 2013/10/11

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KW - graphene-coated nanostructures

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KW - stem cell differentiation

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Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Abstract

Keywords

ASJC Scopus subject areas

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