Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki, Sy Tsong Dean Chueng, Perry T. Yin, Rajesh Kappera, Manish Chhowalla, Ki Bum Lee

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Original languageEnglish
Pages (from-to)5477-5482
Number of pages6
JournalAdvanced Materials
Volume25
Issue number38
DOIs
Publication statusPublished - 2013

Fingerprint

Graphite
Stem cells
Graphene
Nanoparticles
Monolayers
Nanostructures

Keywords

  • axonal alignment
  • graphene-coated nanostructures
  • neural stem cells
  • stem cell differentiation

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures. / Solanki, Aniruddh; Chueng, Sy Tsong Dean; Yin, Perry T.; Kappera, Rajesh; Chhowalla, Manish; Lee, Ki Bum.

In: Advanced Materials, Vol. 25, No. 38, 2013, p. 5477-5482.

Research output: Contribution to journalArticle

Solanki, Aniruddh ; Chueng, Sy Tsong Dean ; Yin, Perry T. ; Kappera, Rajesh ; Chhowalla, Manish ; Lee, Ki Bum. / Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures. In: Advanced Materials. 2013 ; Vol. 25, No. 38. pp. 5477-5482.
@article{a31e93dd50e0497b84669f925f9b0981,
title = "Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures",
abstract = "Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.",
keywords = "axonal alignment, graphene-coated nanostructures, neural stem cells, stem cell differentiation",
author = "Aniruddh Solanki and Chueng, {Sy Tsong Dean} and Yin, {Perry T.} and Rajesh Kappera and Manish Chhowalla and Lee, {Ki Bum}",
year = "2013",
doi = "10.1002/adma.201302219",
language = "English",
volume = "25",
pages = "5477--5482",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "38",

}

TY - JOUR

T1 - Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

AU - Solanki, Aniruddh

AU - Chueng, Sy Tsong Dean

AU - Yin, Perry T.

AU - Kappera, Rajesh

AU - Chhowalla, Manish

AU - Lee, Ki Bum

PY - 2013

Y1 - 2013

N2 - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

AB - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

KW - axonal alignment

KW - graphene-coated nanostructures

KW - neural stem cells

KW - stem cell differentiation

UR - http://www.scopus.com/inward/record.url?scp=84885862560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885862560&partnerID=8YFLogxK

U2 - 10.1002/adma.201302219

DO - 10.1002/adma.201302219

M3 - Article

C2 - 23824715

AN - SCOPUS:84885862560

VL - 25

SP - 5477

EP - 5482

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 38

ER -