Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki; Sy Tsong Dean Chueng; Perry T. Yin; Rajesh Kappera; Manish Chhowalla; Ki Bum Lee

doi:10.1002/adma.201302219

Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki, Sy Tsong Dean Chueng, Perry T. Yin, Rajesh Kappera, Manish Chhowalla, Ki Bum Lee

Rutgers University

Research output: Contribution to journal › Article

114 Citations (Scopus)

Abstract

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Original language	English
Pages (from-to)	5477-5482
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	38
DOIs	https://doi.org/10.1002/adma.201302219
Publication status	Published - Jul 9 2013

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Keywords

axonal alignment
graphene-coated nanostructures
neural stem cells
stem cell differentiation

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

Solanki, A., Chueng, S. T. D., Yin, P. T., Kappera, R., Chhowalla, M., & Lee, K. B. (2013). Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures. Advanced Materials, 25(38), 5477-5482. https://doi.org/10.1002/adma.201302219

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Access to Document

10.1002/adma.201302219