AXSIS

Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy

F. X. Kärtner, F. Ahr, A. L. Calendron, H. Çankaya, S. Carbajo, G. Chang, G. Cirmi, K. Dörner, U. Dorda, A. Fallahi, A. Hartin, M. Hemmer, R. Hobbs, Y. Hua, W. R. Huang, R. Letrun, N. Matlis, V. Mazalova, O. D. Mücke, E. Nanni & 17 others W. Putnam, K. Ravi, F. Reichert, I. Sarrou, X. Wu, A. Yahaghi, H. Ye, L. Zapata, D. Zhang, C. Zhou, R. J D Miller, K. K. Berggren, H. Graafsma, A. Meents, R. W. Assmann, H. N. Chapman, Petra Fromme

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

X-ray crystallography is one of the main methods to determine atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes consisting of hundred-thousands of atoms that constitute the macromolecular machinery of life. Life is not static, and unravelling the structure and dynamics of the most important reactions in chemistry and biology is essential to uncover their mechanism. Many of these reactions, including photosynthesis which drives our biosphere, are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by optical spectroscopy, enabled by ultrafast laser technology, but they reduce the vast complexity of the process to a few reaction coordinates. In the AXSIS project at CFEL in Hamburg, funded by the European Research Council, we develop the new method of attosecond serial X-ray crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology like energy conversion processes. For that purpose, we develop a compact, fully coherent, THz-driven attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals. This highly synergistic project starts from a completely clean slate rather than conforming to the specifications of a large free-electron laser (FEL) user facility, to optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. A multidisciplinary team formed by laser-, accelerator,- X-ray scientists as well as spectroscopists and biochemists optimizes X-ray pulse parameters, in tandem with sample delivery, crystal size, and advanced X-ray detectors. Ultimately, the new capability, attosecond serial X-ray crystallography and spectroscopy, will be applied to one of the most important problems in structural biology, which is to elucidate the dynamics of light reactions, electron transfer and protein structure in photosynthesis.

Fingerprint

Spectroscopy
Imaging techniques
X rays
X ray crystallography
spectroscopy
x rays
Photosynthesis
X ray spectroscopy
biology
crystallography
photosynthesis
Compton scattering
Proteins
Slate
Ultrafast lasers
Crystals
Electrons
Excitation energy
Free electron lasers
Radiation damage

Keywords

  • Attosecond X-ray source
  • Optical undulator
  • Terahertz accelerator
  • X-ray imaging
  • X-ray spectroscopy

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

AXSIS : Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy. / Kärtner, F. X.; Ahr, F.; Calendron, A. L.; Çankaya, H.; Carbajo, S.; Chang, G.; Cirmi, G.; Dörner, K.; Dorda, U.; Fallahi, A.; Hartin, A.; Hemmer, M.; Hobbs, R.; Hua, Y.; Huang, W. R.; Letrun, R.; Matlis, N.; Mazalova, V.; Mücke, O. D.; Nanni, E.; Putnam, W.; Ravi, K.; Reichert, F.; Sarrou, I.; Wu, X.; Yahaghi, A.; Ye, H.; Zapata, L.; Zhang, D.; Zhou, C.; Miller, R. J D; Berggren, K. K.; Graafsma, H.; Meents, A.; Assmann, R. W.; Chapman, H. N.; Fromme, Petra.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 13.01.2016.

Research output: Contribution to journalArticle

Kärtner, FX, Ahr, F, Calendron, AL, Çankaya, H, Carbajo, S, Chang, G, Cirmi, G, Dörner, K, Dorda, U, Fallahi, A, Hartin, A, Hemmer, M, Hobbs, R, Hua, Y, Huang, WR, Letrun, R, Matlis, N, Mazalova, V, Mücke, OD, Nanni, E, Putnam, W, Ravi, K, Reichert, F, Sarrou, I, Wu, X, Yahaghi, A, Ye, H, Zapata, L, Zhang, D, Zhou, C, Miller, RJD, Berggren, KK, Graafsma, H, Meents, A, Assmann, RW, Chapman, HN & Fromme, P 2016, 'AXSIS: Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. https://doi.org/10.1016/j.nima.2016.02.080
Kärtner, F. X. ; Ahr, F. ; Calendron, A. L. ; Çankaya, H. ; Carbajo, S. ; Chang, G. ; Cirmi, G. ; Dörner, K. ; Dorda, U. ; Fallahi, A. ; Hartin, A. ; Hemmer, M. ; Hobbs, R. ; Hua, Y. ; Huang, W. R. ; Letrun, R. ; Matlis, N. ; Mazalova, V. ; Mücke, O. D. ; Nanni, E. ; Putnam, W. ; Ravi, K. ; Reichert, F. ; Sarrou, I. ; Wu, X. ; Yahaghi, A. ; Ye, H. ; Zapata, L. ; Zhang, D. ; Zhou, C. ; Miller, R. J D ; Berggren, K. K. ; Graafsma, H. ; Meents, A. ; Assmann, R. W. ; Chapman, H. N. ; Fromme, Petra. / AXSIS : Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016.
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TY - JOUR

T1 - AXSIS

T2 - Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy

AU - Kärtner, F. X.

AU - Ahr, F.

AU - Calendron, A. L.

AU - Çankaya, H.

AU - Carbajo, S.

AU - Chang, G.

AU - Cirmi, G.

AU - Dörner, K.

AU - Dorda, U.

AU - Fallahi, A.

AU - Hartin, A.

AU - Hemmer, M.

AU - Hobbs, R.

AU - Hua, Y.

AU - Huang, W. R.

AU - Letrun, R.

AU - Matlis, N.

AU - Mazalova, V.

AU - Mücke, O. D.

AU - Nanni, E.

AU - Putnam, W.

AU - Ravi, K.

AU - Reichert, F.

AU - Sarrou, I.

AU - Wu, X.

AU - Yahaghi, A.

AU - Ye, H.

AU - Zapata, L.

AU - Zhang, D.

AU - Zhou, C.

AU - Miller, R. J D

AU - Berggren, K. K.

AU - Graafsma, H.

AU - Meents, A.

AU - Assmann, R. W.

AU - Chapman, H. N.

AU - Fromme, Petra

PY - 2016/1/13

Y1 - 2016/1/13

N2 - X-ray crystallography is one of the main methods to determine atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes consisting of hundred-thousands of atoms that constitute the macromolecular machinery of life. Life is not static, and unravelling the structure and dynamics of the most important reactions in chemistry and biology is essential to uncover their mechanism. Many of these reactions, including photosynthesis which drives our biosphere, are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by optical spectroscopy, enabled by ultrafast laser technology, but they reduce the vast complexity of the process to a few reaction coordinates. In the AXSIS project at CFEL in Hamburg, funded by the European Research Council, we develop the new method of attosecond serial X-ray crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology like energy conversion processes. For that purpose, we develop a compact, fully coherent, THz-driven attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals. This highly synergistic project starts from a completely clean slate rather than conforming to the specifications of a large free-electron laser (FEL) user facility, to optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. A multidisciplinary team formed by laser-, accelerator,- X-ray scientists as well as spectroscopists and biochemists optimizes X-ray pulse parameters, in tandem with sample delivery, crystal size, and advanced X-ray detectors. Ultimately, the new capability, attosecond serial X-ray crystallography and spectroscopy, will be applied to one of the most important problems in structural biology, which is to elucidate the dynamics of light reactions, electron transfer and protein structure in photosynthesis.

AB - X-ray crystallography is one of the main methods to determine atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes consisting of hundred-thousands of atoms that constitute the macromolecular machinery of life. Life is not static, and unravelling the structure and dynamics of the most important reactions in chemistry and biology is essential to uncover their mechanism. Many of these reactions, including photosynthesis which drives our biosphere, are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by optical spectroscopy, enabled by ultrafast laser technology, but they reduce the vast complexity of the process to a few reaction coordinates. In the AXSIS project at CFEL in Hamburg, funded by the European Research Council, we develop the new method of attosecond serial X-ray crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology like energy conversion processes. For that purpose, we develop a compact, fully coherent, THz-driven attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals. This highly synergistic project starts from a completely clean slate rather than conforming to the specifications of a large free-electron laser (FEL) user facility, to optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. A multidisciplinary team formed by laser-, accelerator,- X-ray scientists as well as spectroscopists and biochemists optimizes X-ray pulse parameters, in tandem with sample delivery, crystal size, and advanced X-ray detectors. Ultimately, the new capability, attosecond serial X-ray crystallography and spectroscopy, will be applied to one of the most important problems in structural biology, which is to elucidate the dynamics of light reactions, electron transfer and protein structure in photosynthesis.

KW - Attosecond X-ray source

KW - Optical undulator

KW - Terahertz accelerator

KW - X-ray imaging

KW - X-ray spectroscopy

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