Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography

Jwa Min Nam, Sang Woo Han, Ki Bum Lee, Xiaogang Liu, Mark A Ratner, Chad A. Mirkin

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Ink flowing from a pen: Direct-write dippen nanolithography of His-tagged proteins (ubiquitin and thioredoxin) has been used to generate biologically active protein nanoarrays with feature sizes as small as 80 nm on nickel oxide surfaces without the need for an applied electric field. The protein molecules in this system seem to diffuse from the Ni-coated atomic force microscopy (AFM) tips to the Ni-coated substrate (see diagram).

Original languageEnglish
Pages (from-to)1246-1249
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number10
DOIs
Publication statusPublished - Feb 27 2004

Fingerprint

Nanolithography
Nickel oxide
Proteins
Thioredoxins
Ubiquitin
Ink
Atomic force microscopy
Electric fields
Molecules
Substrates
nickel monoxide

Keywords

  • Atomic force microscopy
  • Nanolithography
  • Nickel
  • Protein arrays
  • Proteins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography. / Nam, Jwa Min; Han, Sang Woo; Lee, Ki Bum; Liu, Xiaogang; Ratner, Mark A; Mirkin, Chad A.

In: Angewandte Chemie - International Edition, Vol. 43, No. 10, 27.02.2004, p. 1246-1249.

Research output: Contribution to journalArticle

Nam, Jwa Min ; Han, Sang Woo ; Lee, Ki Bum ; Liu, Xiaogang ; Ratner, Mark A ; Mirkin, Chad A. / Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography. In: Angewandte Chemie - International Edition. 2004 ; Vol. 43, No. 10. pp. 1246-1249.
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