Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

Mariam Al Shamsi, Mohammed T. Al Samri, Suhail Al-Salam, Walter Conca, Sami Shaban, Sheela Benedict, Saeed Tariq, Ankush V. Biradar, Harvey S. Penefsky, Teddy Asefa, Abdul Kader Souid

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

Original languageEnglish
Pages (from-to)1796-1805
Number of pages10
JournalChemical Research in Toxicology
Volume23
Issue number11
DOIs
Publication statusPublished - Nov 15 2010

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Biocompatibility
Silicon Dioxide
Energy Metabolism
Tissue
Cell Respiration
Histology
Liver
Electron microscopy
Optical microscopy
Microscopy
Electron Microscopy
Spleen
Kidney
Light
Lung
In Vitro Techniques

ASJC Scopus subject areas

  • Toxicology

Cite this

Al Shamsi, M., Al Samri, M. T., Al-Salam, S., Conca, W., Shaban, S., Benedict, S., ... Souid, A. K. (2010). Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues. Chemical Research in Toxicology, 23(11), 1796-1805. https://doi.org/10.1021/tx100245j

Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues. / Al Shamsi, Mariam; Al Samri, Mohammed T.; Al-Salam, Suhail; Conca, Walter; Shaban, Sami; Benedict, Sheela; Tariq, Saeed; Biradar, Ankush V.; Penefsky, Harvey S.; Asefa, Teddy; Souid, Abdul Kader.

In: Chemical Research in Toxicology, Vol. 23, No. 11, 15.11.2010, p. 1796-1805.

Research output: Contribution to journalArticle

Al Shamsi, M, Al Samri, MT, Al-Salam, S, Conca, W, Shaban, S, Benedict, S, Tariq, S, Biradar, AV, Penefsky, HS, Asefa, T & Souid, AK 2010, 'Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues', Chemical Research in Toxicology, vol. 23, no. 11, pp. 1796-1805. https://doi.org/10.1021/tx100245j
Al Shamsi, Mariam ; Al Samri, Mohammed T. ; Al-Salam, Suhail ; Conca, Walter ; Shaban, Sami ; Benedict, Sheela ; Tariq, Saeed ; Biradar, Ankush V. ; Penefsky, Harvey S. ; Asefa, Teddy ; Souid, Abdul Kader. / Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues. In: Chemical Research in Toxicology. 2010 ; Vol. 23, No. 11. pp. 1796-1805.
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