Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

Mariam Al Shamsi, Mohammed T. Al Samri, Suhail Al-Salam, Walter Conca, Sami Shaban, Sheela Benedict, Saeed Tariq, Ankush V. Biradar, Harvey S. Penefsky, Tewodros Asefa, Abdul Kader Souid

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Abstract

A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

Original languageEnglish
Pages (from-to)1796-1805
Number of pages10
JournalChemical Research in Toxicology
Volume23
Issue number11
DOIs
Publication statusPublished - Nov 15 2010

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ASJC Scopus subject areas

  • Toxicology

Cite this

Al Shamsi, M., Al Samri, M. T., Al-Salam, S., Conca, W., Shaban, S., Benedict, S., Tariq, S., Biradar, A. V., Penefsky, H. S., Asefa, T., & Souid, A. K. (2010). Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues. Chemical Research in Toxicology, 23(11), 1796-1805. https://doi.org/10.1021/tx100245j