Abstract
Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.
| Original language | English |
|---|---|
| Pages (from-to) | 65-67 |
| Number of pages | 3 |
| Journal | Inorganic Chemistry Communications |
| Volume | 22 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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Keywords
- Amino acid complexes
- Bioinorganic ligands
- Bioinspired complexes
ASJC Scopus subject areas
- Inorganic Chemistry
- Physical and Theoretical Chemistry
- Materials Chemistry
Cite this
Biologically inspired phosphino platinum complexes. / Jain, Avijita; Helm, Monte; Linehan, John; DuBois, Daniel L; Shaw, Wendy J.
In: Inorganic Chemistry Communications, Vol. 22, 08.2012, p. 65-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biologically inspired phosphino platinum complexes
AU - Jain, Avijita
AU - Helm, Monte
AU - Linehan, John
AU - DuBois, Daniel L
AU - Shaw, Wendy J.
PY - 2012/8
Y1 - 2012/8
N2 - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.
AB - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.
KW - Amino acid complexes
KW - Bioinorganic ligands
KW - Bioinspired complexes
UR - http://www.scopus.com/inward/record.url?scp=84863319291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863319291&partnerID=8YFLogxK
U2 - 10.1016/j.inoche.2012.04.039
DO - 10.1016/j.inoche.2012.04.039
M3 - Article
AN - SCOPUS:84863319291
VL - 22
SP - 65
EP - 67
JO - Inorganic Chemistry Communication
JF - Inorganic Chemistry Communication
SN - 1387-7003
ER -