Biologically inspired phosphino platinum complexes

Avijita Jain; Monte L. Helm; John C. Linehan; Daniel L. Dubois; Wendy J. Shaw

doi:10.1016/j.inoche.2012.04.039

Biologically inspired phosphino platinum complexes

Avijita Jain, Monte L. Helm, John C. Linehan, Daniel L. Dubois, Wendy J. Shaw

Pacific Northwest National Laboratory

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P ^PhN ^R′ ₂ platform, have been synthesized and characterized (P ^PhN ^R′ ₂ = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by ³¹P, ¹³C, ¹H, ¹⁹⁵Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl ₂(P ^PhN ^Gly-ester ₂) ₂], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

Original language	English
Pages (from-to)	65-67
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	22
DOIs	https://doi.org/10.1016/j.inoche.2012.04.039
Publication status	Published - Aug 1 2012

Fingerprint

Keywords

Amino acid complexes
Bioinorganic ligands
Bioinspired complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Cite this

Jain, A., Helm, M. L., Linehan, J. C., Dubois, D. L., & Shaw, W. J. (2012). Biologically inspired phosphino platinum complexes. Inorganic Chemistry Communications, 22, 65-67. https://doi.org/10.1016/j.inoche.2012.04.039

@article{9ce4294a579947fead0972288c15867b,

title = "Biologically inspired phosphino platinum complexes",

abstract = "Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.",

keywords = "Amino acid complexes, Bioinorganic ligands, Bioinspired complexes",

author = "Avijita Jain and Helm, {Monte L.} and Linehan, {John C.} and Dubois, {Daniel L.} and Shaw, {Wendy J.}",

year = "2012",

month = aug

day = "1",

doi = "10.1016/j.inoche.2012.04.039",

language = "English",

volume = "22",

pages = "65--67",

journal = "Inorganic Chemistry Communication",

issn = "1387-7003",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Biologically inspired phosphino platinum complexes

AU - Jain, Avijita

AU - Helm, Monte L.

AU - Linehan, John C.

AU - Dubois, Daniel L.

AU - Shaw, Wendy J.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

AB - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

KW - Amino acid complexes

KW - Bioinorganic ligands

KW - Bioinspired complexes

UR - http://www.scopus.com/inward/record.url?scp=84863319291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863319291&partnerID=8YFLogxK

U2 - 10.1016/j.inoche.2012.04.039

DO - 10.1016/j.inoche.2012.04.039

M3 - Article

AN - SCOPUS:84863319291

VL - 22

SP - 65

EP - 67

JO - Inorganic Chemistry Communication

JF - Inorganic Chemistry Communication

SN - 1387-7003

ER -

Access to Document

10.1016/j.inoche.2012.04.039