TY - JOUR
T1 - Biologically inspired phosphino platinum complexes
AU - Jain, Avijita
AU - Helm, Monte L.
AU - Linehan, John C.
AU - Dubois, Daniel L.
AU - Shaw, Wendy J.
N1 - Funding Information:
This work was supported by the US Department of Energy Basic Energy Sciences, Chemical Sciences, Geosciences & Biosciences Division . Pacific Northwest National Laboratory is operated by Battelle for the US Department of Energy.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/8
Y1 - 2012/8
N2 - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.
AB - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.
KW - Amino acid complexes
KW - Bioinorganic ligands
KW - Bioinspired complexes
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U2 - 10.1016/j.inoche.2012.04.039
DO - 10.1016/j.inoche.2012.04.039
M3 - Article
AN - SCOPUS:84863319291
VL - 22
SP - 65
EP - 67
JO - Inorganic Chemistry Communication
JF - Inorganic Chemistry Communication
SN - 1387-7003
ER -