Biologically inspired phosphino platinum complexes

Avijita Jain, Monte Helm, John Linehan, Daniel L DuBois, Wendy J. Shaw

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalInorganic Chemistry Communications
Volume22
DOIs
Publication statusPublished - Aug 2012

Fingerprint

glycine
Platinum
Glycine
Amino acids
esters
Esters
platinum
Amino Acids
amino acids
Nuclear magnetic resonance spectroscopy
Mass spectrometry
Crystal structure
Ligands
X rays
Peptides
Catalysts
peptides
Geometry
enzymes
Enzymes

Keywords

  • Amino acid complexes
  • Bioinorganic ligands
  • Bioinspired complexes

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Biologically inspired phosphino platinum complexes. / Jain, Avijita; Helm, Monte; Linehan, John; DuBois, Daniel L; Shaw, Wendy J.

In: Inorganic Chemistry Communications, Vol. 22, 08.2012, p. 65-67.

Research output: Contribution to journalArticle

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