Biologically inspired phosphino platinum complexes

Avijita Jain; Monte L. Helm; John C. Linehan; Daniel L. Dubois; Wendy J. Shaw

doi:10.1016/j.inoche.2012.04.039

Biologically inspired phosphino platinum complexes

Avijita Jain, Monte L. Helm, John C. Linehan, Daniel L. Dubois, Wendy J. Shaw

Pacific Northwest National Laboratory

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P ^PhN ^R′ ₂ platform, have been synthesized and characterized (P ^PhN ^R′ ₂ = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by ³¹P, ¹³C, ¹H, ¹⁹⁵Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl ₂(P ^PhN ^Gly-ester ₂) ₂], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

Original language	English
Pages (from-to)	65-67
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	22
DOIs	https://doi.org/10.1016/j.inoche.2012.04.039
Publication status	Published - Aug 1 2012

Keywords

Amino acid complexes
Bioinorganic ligands
Bioinspired complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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@article{9ce4294a579947fead0972288c15867b,

title = "Biologically inspired phosphino platinum complexes",

abstract = "Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.",

keywords = "Amino acid complexes, Bioinorganic ligands, Bioinspired complexes",

author = "Avijita Jain and Helm, {Monte L.} and Linehan, {John C.} and Dubois, {Daniel L.} and Shaw, {Wendy J.}",

year = "2012",

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day = "1",

doi = "10.1016/j.inoche.2012.04.039",

language = "English",

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pages = "65--67",

journal = "Inorganic Chemistry Communication",

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TY - JOUR

T1 - Biologically inspired phosphino platinum complexes

AU - Jain, Avijita

AU - Helm, Monte L.

AU - Linehan, John C.

AU - Dubois, Daniel L.

AU - Shaw, Wendy J.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

AB - Platinum complexes containing phosphino amino acid and amino acid ester ligands, built upon the P PhN R′ 2 platform, have been synthesized and characterized (P PhN R′ 2 = [1,3-diaza]-5-phenyl phosphacyclohexane), R' = Gly (glycine) or Gly-ester (glycine ethyl ester). These complexes were characterized by 31P, 13C, 1H, 195Pt NMR spectroscopy, and mass spectrometry. The X-ray crystal structure of one of the complexes, [PtCl 2(P PhN Gly-ester 2) 2], is reported, confirming cis-square planar geometry about the platinum. These complexes provide a foundation upon which larger peptides can be attached, to allow the introduction of enzyme-like features onto small molecular catalysts.

KW - Amino acid complexes

KW - Bioinorganic ligands

KW - Bioinspired complexes

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