Abstract
In order to better understand how mineral-rich tissues are formed in vivo, the study of biomineralization is important. Biomineralization is also useful for the conception of advanced materials. There have been great progress in the study of hydroxyapatite (HA) biomineralization in mammalian tissues like bone, dentin, and enamel. The role of proteins in achieving a morphologically controlled deposition of mineral as opposed to precipitation of unstructured agglomerates of crystals have been obtained and are now existing. Such understanding of the complex integration of hard and soft phases that biology achieves in mineralized matrices across scales and its link to properties is knowledge of great value to materials chemistry. As such, a study has been conducted on the formation of hydroxyapatite in synthetic systems designed primarily in the biomimetic context of bone or enamel mineralization for therapeutic approaches in repair of human tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 4754-4783 |
| Number of pages | 30 |
| Journal | Chemical Reviews |
| Volume | 108 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2008 |
Fingerprint
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel. / Palmer, Liam C.; Newcomb, Christina J.; Kaltz, Stuart R.; Spoerke, Erik D.; Stupp, Samuel I.
In: Chemical Reviews, Vol. 108, No. 11, 11.2008, p. 4754-4783.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel
AU - Palmer, Liam C.
AU - Newcomb, Christina J.
AU - Kaltz, Stuart R.
AU - Spoerke, Erik D.
AU - Stupp, Samuel I
PY - 2008/11
Y1 - 2008/11
N2 - In order to better understand how mineral-rich tissues are formed in vivo, the study of biomineralization is important. Biomineralization is also useful for the conception of advanced materials. There have been great progress in the study of hydroxyapatite (HA) biomineralization in mammalian tissues like bone, dentin, and enamel. The role of proteins in achieving a morphologically controlled deposition of mineral as opposed to precipitation of unstructured agglomerates of crystals have been obtained and are now existing. Such understanding of the complex integration of hard and soft phases that biology achieves in mineralized matrices across scales and its link to properties is knowledge of great value to materials chemistry. As such, a study has been conducted on the formation of hydroxyapatite in synthetic systems designed primarily in the biomimetic context of bone or enamel mineralization for therapeutic approaches in repair of human tissues.
AB - In order to better understand how mineral-rich tissues are formed in vivo, the study of biomineralization is important. Biomineralization is also useful for the conception of advanced materials. There have been great progress in the study of hydroxyapatite (HA) biomineralization in mammalian tissues like bone, dentin, and enamel. The role of proteins in achieving a morphologically controlled deposition of mineral as opposed to precipitation of unstructured agglomerates of crystals have been obtained and are now existing. Such understanding of the complex integration of hard and soft phases that biology achieves in mineralized matrices across scales and its link to properties is knowledge of great value to materials chemistry. As such, a study has been conducted on the formation of hydroxyapatite in synthetic systems designed primarily in the biomimetic context of bone or enamel mineralization for therapeutic approaches in repair of human tissues.
UR - http://www.scopus.com/inward/record.url?scp=57349116196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57349116196&partnerID=8YFLogxK
U2 - 10.1021/cr8004422
DO - 10.1021/cr8004422
M3 - Article
C2 - 19006400
AN - SCOPUS:57349116196
VL - 108
SP - 4754
EP - 4783
JO - Chemical Reviews
JF - Chemical Reviews
SN - 0009-2665
IS - 11
ER -