Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel

Liam C. Palmer, Christina J. Newcomb, Stuart R. Kaltz, Erik D. Spoerke, Samuel I. Stupp

Research output: Contribution to journalArticle

674 Citations (Scopus)

Abstract

In order to better understand how mineral-rich tissues are formed in vivo, the study of biomineralization is important. Biomineralization is also useful for the conception of advanced materials. There have been great progress in the study of hydroxyapatite (HA) biomineralization in mammalian tissues like bone, dentin, and enamel. The role of proteins in achieving a morphologically controlled deposition of mineral as opposed to precipitation of unstructured agglomerates of crystals have been obtained and are now existing. Such understanding of the complex integration of hard and soft phases that biology achieves in mineralized matrices across scales and its link to properties is knowledge of great value to materials chemistry. As such, a study has been conducted on the formation of hydroxyapatite in synthetic systems designed primarily in the biomimetic context of bone or enamel mineralization for therapeutic approaches in repair of human tissues.

Original languageEnglish
Pages (from-to)4754-4783
Number of pages30
JournalChemical reviews
Volume108
Issue number11
DOIs
Publication statusPublished - Nov 1 2008

ASJC Scopus subject areas

  • Chemistry(all)

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