Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy

Bhavya Sharma, Pradeep Bugga, Lindsey R. Madison, Anne Isabelle Henry, Martin G. Blaber, Nathan G. Greeneltch, Naihao Chiang, Milan Mrksich, George C Schatz, Richard P. Van Duyne

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

This paper demonstrates the direct sensing of glucose at physiologically relevant concentrations with surface-enhanced Raman spectroscopy (SERS) on gold film-over-nanosphere (AuFON) substrates functionalized with bisboronic acid receptors. The combination of selectivity in the bisboronic acid receptor and spectral resolution in the SERS data allow the sensors to resolve glucose in high backgrounds of fructose and, in combination with multivariate statistical analysis, detect glucose accurately in the 1-10 mM range. Computational modeling supports assignments of the normal modes and vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose. These results are promising for the use of bisboronic acids as receptors in SERS-based in vivo glucose monitoring sensors.

Original languageEnglish
Pages (from-to)13952-13959
Number of pages8
JournalJournal of the American Chemical Society
Volume138
Issue number42
DOIs
Publication statusPublished - Oct 26 2016

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Raman Spectrum Analysis
Glucose
Raman spectroscopy
Acids
Fructose
Nanospheres
Spectral resolution
Sensors
Vibrational spectra
Gold
Statistical methods
Multivariate Analysis
Monitoring
Substrates

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Sharma, B., Bugga, P., Madison, L. R., Henry, A. I., Blaber, M. G., Greeneltch, N. G., ... Van Duyne, R. P. (2016). Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy. Journal of the American Chemical Society, 138(42), 13952-13959. https://doi.org/10.1021/jacs.6b07331

Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy. / Sharma, Bhavya; Bugga, Pradeep; Madison, Lindsey R.; Henry, Anne Isabelle; Blaber, Martin G.; Greeneltch, Nathan G.; Chiang, Naihao; Mrksich, Milan; Schatz, George C; Van Duyne, Richard P.

In: Journal of the American Chemical Society, Vol. 138, No. 42, 26.10.2016, p. 13952-13959.

Research output: Contribution to journalArticle

Sharma, B, Bugga, P, Madison, LR, Henry, AI, Blaber, MG, Greeneltch, NG, Chiang, N, Mrksich, M, Schatz, GC & Van Duyne, RP 2016, 'Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy', Journal of the American Chemical Society, vol. 138, no. 42, pp. 13952-13959. https://doi.org/10.1021/jacs.6b07331
Sharma, Bhavya ; Bugga, Pradeep ; Madison, Lindsey R. ; Henry, Anne Isabelle ; Blaber, Martin G. ; Greeneltch, Nathan G. ; Chiang, Naihao ; Mrksich, Milan ; Schatz, George C ; Van Duyne, Richard P. / Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy. In: Journal of the American Chemical Society. 2016 ; Vol. 138, No. 42. pp. 13952-13959.
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