Bond activation by metal-ligand cooperation: Design of "green" catalytic reactions based on aromatization-dearomatization of pincer complexes

Chidambaram Gunanathan, David Milstein

Research output: Chapter in Book/Report/Conference proceedingChapter

103 Citations (Scopus)

Abstract

We have developed a new mode of bifunctional catalysis based on metal-ligand cooperation, involving aromatization-dearomatization of pyridine- and acridine-derived pincer complexes. This type of metal-ligand cooperation is involved in the recently discovered environmentally benign reactions of alcohols, catalyzed by PNP and PNN pincer complexes of ruthenium, including: (a) dehydrogenation of secondary alcohols to ketones, (b) dehydrogenative coupling of primary alcohols to form esters and H2, (c) unprecedented amide synthesis: catalytic coupling of amines with alcohols, with liberation of H 2, (d) direct synthesis of imines from alcohols and amines with H2 liberation, (e) direct conversion of alcohols to acetals with H2 liberation, (f) selective synthesis of primary amines from alcohols and ammonia, and (g) hydrogenation of esters to alcohols under mild conditions. These reactions are very efficient, proceed under neutral conditions, and produce no waste.

Original languageEnglish
Title of host publicationBifunctional Molecular Catalysis
EditorsTakao Ikariya, Masakatsu Shibasaki
Pages55-84
Number of pages30
DOIs
Publication statusPublished - Jul 29 2011

Publication series

NameTopics in Organometallic Chemistry
Volume37
ISSN (Print)1436-6002

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Keywords

  • Alcohols
  • Amides
  • Amines
  • Carbon dioxide
  • Catalysis
  • Dehydrogenative coupling
  • Esters
  • Hydrogen
  • Imines
  • Iridium
  • Metal-ligand cooperation
  • O-H activation
  • PNN
  • PNP
  • Pincer complexes
  • Ruthenium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Gunanathan, C., & Milstein, D. (2011). Bond activation by metal-ligand cooperation: Design of "green" catalytic reactions based on aromatization-dearomatization of pincer complexes. In T. Ikariya, & M. Shibasaki (Eds.), Bifunctional Molecular Catalysis (pp. 55-84). (Topics in Organometallic Chemistry; Vol. 37). https://doi.org/10.1007/3418_2011_6