Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix

Alvaro Mata, Yanbiao Geng, Karl J. Henrikson, Conrado Aparicio, Stuart R. Stock, Robert L. Satcher, Samuel I Stupp

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Rapid bone regeneration within a three-dimensional defect without the use of bone grafts, exogenous growth factors, or cells remains a major challenge. We report here on the use of self-assembling peptide nanostructured gels to promote bone regeneration that have the capacity to mineralize in biomimetic fashion. The main molecular design was the use of phosphoserine residues in the sequence of a peptide amphiphile known to nucleate hydroxyapatite crystals on the surfaces of nanofibers. We tested the system in a rat femoral critical-size defect by placing pre-assembled nanofiber gels in a 5. mm gap and analyzed bone formation with micro-computed tomography and histology. We found within 4 weeks significantly higher bone formation relative to controls lacking phosphorylated residues and comparable bone formation to that observed in animals treated with a clinically used allogenic bone matrix.

Original languageEnglish
Pages (from-to)6004-6012
Number of pages9
JournalBiomaterials
Volume31
Issue number23
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Nanofibers
Biomimetics
Bone Regeneration
Osteogenesis
Bone
Gels
Phosphoserine
Peptides
Bone Matrix
Durapatite
Thigh
Intercellular Signaling Peptides and Proteins
Histology
Tomography
Transplants
Bone and Bones
Defects
Amphiphiles
Hydroxyapatite
Grafts

Keywords

  • Biomaterials
  • Biomineralization
  • Bone regeneration
  • Bone scaffolds
  • Peptide amphiphiles
  • Regenerative medicine

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics
  • Medicine(all)

Cite this

Mata, A., Geng, Y., Henrikson, K. J., Aparicio, C., Stock, S. R., Satcher, R. L., & Stupp, S. I. (2010). Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials, 31(23), 6004-6012. https://doi.org/10.1016/j.biomaterials.2010.04.013

Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. / Mata, Alvaro; Geng, Yanbiao; Henrikson, Karl J.; Aparicio, Conrado; Stock, Stuart R.; Satcher, Robert L.; Stupp, Samuel I.

In: Biomaterials, Vol. 31, No. 23, 08.2010, p. 6004-6012.

Research output: Contribution to journalArticle

Mata, A, Geng, Y, Henrikson, KJ, Aparicio, C, Stock, SR, Satcher, RL & Stupp, SI 2010, 'Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix', Biomaterials, vol. 31, no. 23, pp. 6004-6012. https://doi.org/10.1016/j.biomaterials.2010.04.013
Mata A, Geng Y, Henrikson KJ, Aparicio C, Stock SR, Satcher RL et al. Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials. 2010 Aug;31(23):6004-6012. https://doi.org/10.1016/j.biomaterials.2010.04.013
Mata, Alvaro ; Geng, Yanbiao ; Henrikson, Karl J. ; Aparicio, Conrado ; Stock, Stuart R. ; Satcher, Robert L. ; Stupp, Samuel I. / Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. In: Biomaterials. 2010 ; Vol. 31, No. 23. pp. 6004-6012.
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