Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods

Casper S. Andersen, Hao Yan, Kurt V. Gothelf

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

(Figure Presented) A molecular bridge: A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10-base-pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal-salen complex.

Original languageEnglish
Pages (from-to)5569-5572
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number30
DOIs
Publication statusPublished - Jul 14 2008

Fingerprint

ethylenediamine
Dimerization
DNA sequences
Coordination Complexes
Metal complexes
Base Pairing
DNA
Salts
Metals
Molecules
disalicylaldehyde ethylenediamine
salicylaldehyde
poly(phenylene ethynylene)

Keywords

  • DNA
  • Metal-salen complexes
  • Molecular electronics
  • Nanostructures
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods. / Andersen, Casper S.; Yan, Hao; Gothelf, Kurt V.

In: Angewandte Chemie - International Edition, Vol. 47, No. 30, 14.07.2008, p. 5569-5572.

Research output: Contribution to journalArticle

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