Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging

Adam T. Preslar, Laura M. Lilley, Kohei Sato, Shanrong Zhang, Zer Keen Chia, Samuel I Stupp, Thomas J. Meade

Research output: Contribution to journalArticle

Abstract

Misregulation of extracellular Ca2+ can indicate bone-related pathologies. New, noninvasive tools are required to image Ca2+ fluxes and fluorine magnetic resonance imaging (19F-MRI) is uniquely suited to this challenge. Here, we present three, highly fluorinated peptide amphiphiles that self-assemble into nanoribbons in buffered saline and demonstrate these nanostructures can be programmed to change 19F-NMR signal intensity as a function of Ca2+ concentration. We determined these nanostructures show significant reduction in 19F-NMR signal as nanoribbon width increases in response to Ca2+, corresponding to 19F-MR image intensity reduction. Thus, these peptide amphiphiles can be used to quantitatively image biologically relevant Ca2+ concentrations.

Original languageEnglish
Pages (from-to)39890-39894
Number of pages5
JournalACS Applied Materials and Interfaces
Volume9
Issue number46
DOIs
Publication statusPublished - Nov 22 2017

Fingerprint

Nanoribbons
Amphiphiles
Carbon Nanotubes
Peptides
Calcium
Nanostructures
Nuclear magnetic resonance
Fluorine
Pathology
Magnetic resonance
Magnetic resonance imaging
Bone
Fluxes
Imaging techniques
Magnetic Resonance Imaging

Keywords

  • F
  • calcium sensing
  • morphology
  • MRI
  • peptide amphiphile

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging. / Preslar, Adam T.; Lilley, Laura M.; Sato, Kohei; Zhang, Shanrong; Chia, Zer Keen; Stupp, Samuel I; Meade, Thomas J.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 46, 22.11.2017, p. 39890-39894.

Research output: Contribution to journalArticle

Preslar, Adam T. ; Lilley, Laura M. ; Sato, Kohei ; Zhang, Shanrong ; Chia, Zer Keen ; Stupp, Samuel I ; Meade, Thomas J. / Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging. In: ACS Applied Materials and Interfaces. 2017 ; Vol. 9, No. 46. pp. 39890-39894.
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