Carotenoporphyrins as selective photodiagnostic agents for tumours

E. Reddi, A. Segalla, G. Jori, P. K. Kerrigan, P. A. Liddell, Ana L Moore, Thomas A Moore, John Devens Gust

Research output: Contribution to journalArticle

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Abstract

The covalent binding of a carotene moiety to one phenyl ring and meso-tetraphenyl-substituted porphyrins (see Figure 1) efficiently quenches the photosensitising activity of the porphyrin while a relatively large yield of fluorescence emission around 650 nm is retained. Pharmacokinetic studies performed with two carotenoporphyrins (CPs) and the corresponding porphyrins (Ps) in Balb/c mice bearing an MS-2 fibrosarcoma show that the two Ps give a high selectivity of tumour localisation (tumour/peritumoral tissue ratios of dye concentration ranging between c. 30 and 90 at 24 h after injection of 4.2-8.4 μmol kg-1 in a Cremophor emulsion) and photosensitise tumour necrosis upon red light irradiation. For the same injected doses, the two CPs show no tumour-photosensitising activity even though they localise in the tumour in concentrations of the order of 10-40 μg g-1 at 24 h with tumour/peritumoral ratios larger than 10 Thus, the fluorescence emitted by these CPs in the tumour can be used for photodiagnostic purposes with no risk of skin photosensitisation. However, this approach is presently limited by the large accumulation and prolonged retention of the CPs in the liver and spleen.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalBritish Journal of Cancer
Volume69
Issue number1
Publication statusPublished - Jan 1994

Fingerprint

Porphyrins
Neoplasms
Fluorescence
Photosensitivity Disorders
Fibrosarcoma
Carotenoids
Emulsions
Necrosis
Coloring Agents
Spleen
Pharmacokinetics
Light
Skin
Injections
Liver

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Reddi, E., Segalla, A., Jori, G., Kerrigan, P. K., Liddell, P. A., Moore, A. L., ... Gust, J. D. (1994). Carotenoporphyrins as selective photodiagnostic agents for tumours. British Journal of Cancer, 69(1), 40-45.

Carotenoporphyrins as selective photodiagnostic agents for tumours. / Reddi, E.; Segalla, A.; Jori, G.; Kerrigan, P. K.; Liddell, P. A.; Moore, Ana L; Moore, Thomas A; Gust, John Devens.

In: British Journal of Cancer, Vol. 69, No. 1, 01.1994, p. 40-45.

Research output: Contribution to journalArticle

Reddi, E, Segalla, A, Jori, G, Kerrigan, PK, Liddell, PA, Moore, AL, Moore, TA & Gust, JD 1994, 'Carotenoporphyrins as selective photodiagnostic agents for tumours', British Journal of Cancer, vol. 69, no. 1, pp. 40-45.
Reddi E, Segalla A, Jori G, Kerrigan PK, Liddell PA, Moore AL et al. Carotenoporphyrins as selective photodiagnostic agents for tumours. British Journal of Cancer. 1994 Jan;69(1):40-45.
Reddi, E. ; Segalla, A. ; Jori, G. ; Kerrigan, P. K. ; Liddell, P. A. ; Moore, Ana L ; Moore, Thomas A ; Gust, John Devens. / Carotenoporphyrins as selective photodiagnostic agents for tumours. In: British Journal of Cancer. 1994 ; Vol. 69, No. 1. pp. 40-45.
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