Catalytic, oxidant-free, direct olefination of alcohols using Wittig reagents

E. Khaskin; D. Milstein

doi:10.1039/c5cc02902c

Catalytic, oxidant-free, direct olefination of alcohols using Wittig reagents

E. Khaskin, D. Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Reported here is the catalytic, acceptorless coupling of alcohols with in situ generated, non-stabilized phosphonium ylides to form olefins as major products. The reaction uses low catalyst loadings and does not require added oxidants. Hydrogenation of the product is minimized and the reaction leads to Z (aliphatic) or E (benzylic) stereospecificity.

Original language	English
Pages (from-to)	9002-9005
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	43
DOIs	https://doi.org/10.1039/c5cc02902c
Publication status	Published - May 28 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Reported here is the catalytic, acceptorless coupling of alcohols with in situ generated, non-stabilized phosphonium ylides to form olefins as major products. The reaction uses low catalyst loadings and does not require added oxidants. Hydrogenation of the product is minimized and the reaction leads to Z (aliphatic) or E (benzylic) stereospecificity.",

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AB - Reported here is the catalytic, acceptorless coupling of alcohols with in situ generated, non-stabilized phosphonium ylides to form olefins as major products. The reaction uses low catalyst loadings and does not require added oxidants. Hydrogenation of the product is minimized and the reaction leads to Z (aliphatic) or E (benzylic) stereospecificity.

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