Challenges and opportunities for structural DNA nanotechnology

Andre V. Pinheiro, Dongran Han, William M. Shih, Hao Yan

Research output: Contribution to journalReview article

784 Citations (Scopus)

Abstract

DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.

Original languageEnglish
Pages (from-to)763-772
Number of pages10
JournalNature nanotechnology
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 2011

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ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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