Challenging metal-based transformations. From single-bond activation to catalysis and metallaquinonoids

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Abstract

Catalytic reactions resulting from our C-X (X = H, C, O, N, halide) bond activation studies are described. Aryl chlorides can react with aluminum alkyls in preference to bromides. Using PCP-type Pd catalysts, Heck reaction with aryl iodides and bromides can proceed without involvement of Pd(0). Ru-catalyzed oxidative coupling of arenes with alkenes using O2 was accomplished. Using specifically designed systems, the scope and mechanisms of C-C activation in solution was studied and compared to C-H activation. C-C activation by Rh(I), Ir(I), Ni(II), Pt(II), Ru(II), and Os(II) was observed. Metal insertion into a strong C-C bond can be kinetically and thermodynamically more favorable than the competing C-H activation. Selective, single-step oxidative addition of a strong C-C bond to a metal was observed and kinetically evaluated. Catalytic C-C hydrogenolysis was demonstrated. A combination of C-C activation and C-R formation (R = aryl, silyl) resulted in unusual methylene transfer chemistry. Selective activation of aryl-O and Me-O bonds was observed. New types of interactions between metals and arenes and unusual quinonoid complexes, including quinone methides, xylylenes, methylene arenium, and a metallaquinone, were discovered. C-H and C-C agostic complexes of cationic metals, proposed as intermediates in bond activation, were isolated. Stabilization and controlled release of biologically relevant, extremely unstable, simple quinone methides, was accomplished.

Original languageEnglish
Pages (from-to)445-460
Number of pages16
JournalPure and Applied Chemistry
Volume75
Issue number4
Publication statusPublished - Apr 1 2003

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Catalysis
Metals
Chemical activation
Bromides
Hydrogenolysis
single bond
Alkenes
Iodides
Aluminum
Olefins
Chlorides
Stabilization
Catalysts

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Challenging metal-based transformations. From single-bond activation to catalysis and metallaquinonoids. / Milstein, David.

In: Pure and Applied Chemistry, Vol. 75, No. 4, 01.04.2003, p. 445-460.

Research output: Contribution to journalArticle

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