Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Richard D Schaller, Justin C. Johnson, Kevin R. Wilson, Lynn F. Lee, Louis H. Haber, Richard J. Saykally

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.S. Edwards, J. Neev, A. Ostendorf, J.C. Sutherland
Pages62-68
Number of pages7
Volume4633
DOIs
Publication statusPublished - 2002
EventCommercial and Biomedical Applications of Ultrafast and Free-Electron Lasers - San Jose, CA, United States
Duration: Jan 23 2002Jan 24 2002

Other

OtherCommercial and Biomedical Applications of Ultrafast and Free-Electron Lasers
CountryUnited States
CitySan Jose, CA
Period1/23/021/24/02

Fingerprint

Harmonic generation
harmonic generations
Near field scanning optical microscopy
Imaging techniques
erythrocytes
near fields
selectivity
Spectroscopy
microscopy
scanning
augmentation
cells
spectroscopy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Schaller, R. D., Johnson, J. C., Wilson, K. R., Lee, L. F., Haber, L. H., & Saykally, R. J. (2002). Characterization of biological structures with nonlinear chemical imaging nanomicroscopy. In G. S. Edwards, J. Neev, A. Ostendorf, & J. C. Sutherland (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4633, pp. 62-68) https://doi.org/10.1117/12.461388

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy. / Schaller, Richard D; Johnson, Justin C.; Wilson, Kevin R.; Lee, Lynn F.; Haber, Louis H.; Saykally, Richard J.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.S. Edwards; J. Neev; A. Ostendorf; J.C. Sutherland. Vol. 4633 2002. p. 62-68.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Schaller, RD, Johnson, JC, Wilson, KR, Lee, LF, Haber, LH & Saykally, RJ 2002, Characterization of biological structures with nonlinear chemical imaging nanomicroscopy. in GS Edwards, J Neev, A Ostendorf & JC Sutherland (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4633, pp. 62-68, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, San Jose, CA, United States, 1/23/02. https://doi.org/10.1117/12.461388
Schaller RD, Johnson JC, Wilson KR, Lee LF, Haber LH, Saykally RJ. Characterization of biological structures with nonlinear chemical imaging nanomicroscopy. In Edwards GS, Neev J, Ostendorf A, Sutherland JC, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4633. 2002. p. 62-68 https://doi.org/10.1117/12.461388
Schaller, Richard D ; Johnson, Justin C. ; Wilson, Kevin R. ; Lee, Lynn F. ; Haber, Louis H. ; Saykally, Richard J. / Characterization of biological structures with nonlinear chemical imaging nanomicroscopy. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.S. Edwards ; J. Neev ; A. Ostendorf ; J.C. Sutherland. Vol. 4633 2002. pp. 62-68
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