Abstract
We optimized the performance of quantum-confined Stark effect (QCSE)-based voltage nanosensors. A high-throughput approach for single-particle QCSE characterization was developed and utilized to screen a library of such nanosensors. Type-II ZnSe/CdS-seeded nanorods were found to have the best performance among the different nanosensors evaluated in this work. The degree of correlation between intensity changes and spectral changes of the exciton's emission under an applied field was characterized. An upper limit for the temporal response of individual ZnSe/CdS nanorods to voltage modulation was characterized by high-throughput, high temporal resolution intensity measurements using a novel photon-counting camera. The measured 3.5 μs response time is limited by the voltage modulation electronics and represents ∼30 times higher bandwidth than needed for recording an action potential in a neuron.
| Original language | English |
|---|---|
| Journal | ACS Photonics |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
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Keywords
- membrane potential
- nanorod
- quantum dot
- quantum-confined Stark effect
- single molecule
- voltage sensor
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biotechnology
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering
Cite this
Characterizing the Quantum-Confined Stark Effect in Semiconductor Quantum Dots and Nanorods for Single-Molecule Electrophysiology. / Kuo, Yung; Li, Jack; Michalet, Xavier; Chizhik, Alexey; Meir, Noga; Bar-Elli, Omri; Chan, Emory; Oron, Dan; Enderlein, Joerg; Weiss, Shimon.
In: ACS Photonics, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterizing the Quantum-Confined Stark Effect in Semiconductor Quantum Dots and Nanorods for Single-Molecule Electrophysiology
AU - Kuo, Yung
AU - Li, Jack
AU - Michalet, Xavier
AU - Chizhik, Alexey
AU - Meir, Noga
AU - Bar-Elli, Omri
AU - Chan, Emory
AU - Oron, Dan
AU - Enderlein, Joerg
AU - Weiss, Shimon
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We optimized the performance of quantum-confined Stark effect (QCSE)-based voltage nanosensors. A high-throughput approach for single-particle QCSE characterization was developed and utilized to screen a library of such nanosensors. Type-II ZnSe/CdS-seeded nanorods were found to have the best performance among the different nanosensors evaluated in this work. The degree of correlation between intensity changes and spectral changes of the exciton's emission under an applied field was characterized. An upper limit for the temporal response of individual ZnSe/CdS nanorods to voltage modulation was characterized by high-throughput, high temporal resolution intensity measurements using a novel photon-counting camera. The measured 3.5 μs response time is limited by the voltage modulation electronics and represents ∼30 times higher bandwidth than needed for recording an action potential in a neuron.
AB - We optimized the performance of quantum-confined Stark effect (QCSE)-based voltage nanosensors. A high-throughput approach for single-particle QCSE characterization was developed and utilized to screen a library of such nanosensors. Type-II ZnSe/CdS-seeded nanorods were found to have the best performance among the different nanosensors evaluated in this work. The degree of correlation between intensity changes and spectral changes of the exciton's emission under an applied field was characterized. An upper limit for the temporal response of individual ZnSe/CdS nanorods to voltage modulation was characterized by high-throughput, high temporal resolution intensity measurements using a novel photon-counting camera. The measured 3.5 μs response time is limited by the voltage modulation electronics and represents ∼30 times higher bandwidth than needed for recording an action potential in a neuron.
KW - membrane potential
KW - nanorod
KW - quantum dot
KW - quantum-confined Stark effect
KW - single molecule
KW - voltage sensor
UR - http://www.scopus.com/inward/record.url?scp=85055813333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055813333&partnerID=8YFLogxK
U2 - 10.1021/acsphotonics.8b00617
DO - 10.1021/acsphotonics.8b00617
M3 - Article
AN - SCOPUS:85055813333
JO - ACS Photonics
JF - ACS Photonics
SN - 2330-4022
ER -