Charge transport within a Three-dimensional DNA nanostructure framework

Na Lu, Hao Pei, Zhilei Ge, Chad R. Simmons, Hao Yan, Chunhai Fan

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Three-dimensional (3D) DNA nanostructures have shown great promise for various applications including molecular sensing and therapeutics. Here we report kinetic studies of DNA-mediated charge transport (CT) within a 3D DNA nanostructure framework. A tetrahedral DNA nanostructure was used to investigate the through-duplex and through-space CT of small redox molecules (methylene blue (MB) and ferrocene (Fc)) that were bound to specific positions above the surface of the gold electrode. CT rate measurements provide unambiguous evidence that the intercalative MB probe undergoes efficient mediated CT over longer distances along the duplex, whereas the nonintercalative Fc probe tunnels electrons through the space. This study sheds new light on DNA-based molecular electronics and on designing high-performance biosensor devices.

Original languageEnglish
Pages (from-to)13148-13151
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number32
DOIs
Publication statusPublished - Aug 15 2012

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Nanostructures
Charge transfer
DNA
Methylene Blue
Molecular electronics
Biosensing Techniques
Electric space charge
Biosensors
Gold
Oxidation-Reduction
Tunnels
Electrodes
Electrons
Equipment and Supplies
Molecules
Kinetics
ferrocene

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Charge transport within a Three-dimensional DNA nanostructure framework. / Lu, Na; Pei, Hao; Ge, Zhilei; Simmons, Chad R.; Yan, Hao; Fan, Chunhai.

In: Journal of the American Chemical Society, Vol. 134, No. 32, 15.08.2012, p. 13148-13151.

Research output: Contribution to journalArticle

Lu, Na ; Pei, Hao ; Ge, Zhilei ; Simmons, Chad R. ; Yan, Hao ; Fan, Chunhai. / Charge transport within a Three-dimensional DNA nanostructure framework. In: Journal of the American Chemical Society. 2012 ; Vol. 134, No. 32. pp. 13148-13151.
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