Cobalt-Catalyzed Hydrogenation of Esters to Alcohols: Unexpected Reactivity Trend Indicates Ester Enolate Intermediacy

Dipankar Srimani, Arup Mukherjee, Alexander F.G. Goldberg, Gregory Leitus, Yael Diskin-Posner, Linda J.W. Shimon, Yehoshoa Ben David, David Milstein

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with precious-metal-based catalysts, with few exceptions. Presented here is the first cobalt-catalyzed hydrogenation of esters to the corresponding alcohols. Unexpectedly, the evidence indicates the unprecedented involvement of ester enolate intermediates. Getting involved: The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with precious-metal-based catalysts. Presented here is the first cobalt-catalyzed hydrogenation of esters to alcohols. Unexpectedly, the evidence indicates the unprecedented involvement of ester enolate intermediates.

Original languageEnglish
Pages (from-to)12357-12360
Number of pages4
JournalAngewandte Chemie - International Edition
Volume54
Issue number42
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • alcohols
  • cobalt
  • esters
  • homogeneous catalysis
  • hydrogenation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Cobalt-Catalyzed Hydrogenation of Esters to Alcohols: Unexpected Reactivity Trend Indicates Ester Enolate Intermediacy'. Together they form a unique fingerprint.

Cite this