Abstract
The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.
| Original language | English |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | Photochemistry and Photobiology |
| Volume | 65 |
| Issue number | 1 |
| Publication status | Published - Jan 1997 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biophysics
Cite this
Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells. / Dhami, Suman; Rumbles, Gary; MacRobert, Alexander J.; Phillips, David.
In: Photochemistry and Photobiology, Vol. 65, No. 1, 01.1997, p. 85-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells
AU - Dhami, Suman
AU - Rumbles, Gary
AU - MacRobert, Alexander J.
AU - Phillips, David
PY - 1997/1
Y1 - 1997/1
N2 - The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.
AB - The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031050525&partnerID=8YFLogxK
M3 - Article
VL - 65
SP - 85
EP - 90
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
SN - 0031-8655
IS - 1
ER -