Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells

Suman Dhami, Gary Rumbles, Alexander J. MacRobert, David Phillips

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalPhotochemistry and Photobiology
Volume65
Issue number1
Publication statusPublished - Jan 1997

Fingerprint

Unilamellar Liposomes
K562 Cells
Fluorescence
aluminum
1,2-Dipalmitoylphosphatidylcholine
fluorescence
Active Biological Transport
decay
Quantum yield
cells
Liposomes
Tumors
tumors
Cells
Neoplasms
aluminum phthalocyanine disulfonate
phthalocyanine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells. / Dhami, Suman; Rumbles, Gary; MacRobert, Alexander J.; Phillips, David.

In: Photochemistry and Photobiology, Vol. 65, No. 1, 01.1997, p. 85-90.

Research output: Contribution to journalArticle

@article{a2dfc40e38ff48d8af29fd9163fd5644,
title = "Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells",
abstract = "The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.",
author = "Suman Dhami and Gary Rumbles and MacRobert, {Alexander J.} and David Phillips",
year = "1997",
month = "1",
language = "English",
volume = "65",
pages = "85--90",
journal = "Photochemistry and Photobiology",
issn = "0031-8655",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells

AU - Dhami, Suman

AU - Rumbles, Gary

AU - MacRobert, Alexander J.

AU - Phillips, David

PY - 1997/1

Y1 - 1997/1

N2 - The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.

AB - The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-α-dipalmitoyl- phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time- resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.

UR - http://www.scopus.com/inward/record.url?scp=0031050525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031050525&partnerID=8YFLogxK

M3 - Article

C2 - 9066287

AN - SCOPUS:0031050525

VL - 65

SP - 85

EP - 90

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

SN - 0031-8655

IS - 1

ER -