Complex wireframe DNA origami nanostructures with multi-arm junction vertices

Fei Zhang, Shuoxing Jiang, Siyu Wu, Yulin Li, Chengde Mao, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Structural DNA nanotechnology and the DNA origami technique, in particular, have provided a range of spatially addressable two- and three-dimensional nanostructures. These structures are, however, typically formed of tightly packed parallel helices. The development of wireframe structures should allow the creation of novel designs with unique functionalities, but engineering complex wireframe architectures with arbitrarily designed connections between selected vertices in three-dimensional space remains a challenge. Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability. In our approach, the vertices are represented by n×4 multi-arm junctions (n=2-10) with controlled angles, and the lines are represented by antiparallel DNA crossover tiles of variable lengths. Scaffold strands are used to integrate the vertices and lines into fully assembled structures displaying intricate architectures. To demonstrate the versatility of the technique, a series of two-dimensional designs including quasi-crystalline patterns and curvilinear arrays or variable curvatures, and three-dimensional designs including a complex snub cube and a reconfigurable Archimedean solid were constructed.

Original languageEnglish
Pages (from-to)779-784
Number of pages6
JournalNature nanotechnology
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 3 2015

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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