Conformational control of thymine photodimerization in purine-containing trinucleotides

Zhengzheng Pan, Martin McCullagh, George C Schatz, Frederick D. Lewis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effects of a flanking purine base on the thymine-thymine photodimerization efficiencies and product distributions have been determined for the trinucleotides 5′-ATT, TTA, GTT, and TTG and the results compared to those for the dinucleotide TT. The highest quantum yield and selectivity for formation of the major cis-syn (2 + 2) dimer was observed for ATT. The relative yields of (2 + 2) and (6 - 4) adduct formation from the four trinucleotides are well-correlated with ground-state conformational populations using the single-parameter model developed in our previous studies of TT dimerization. The effect of the flanking purine base is determined mainly by its influence on the extent of TT ground-state stacking, which is more extensive for A versus G. The low probability of stacking of all three nucleotides and the fast decay times of the nucleotide excited states can account for the apparent absence of electronic interactions between thymines and the flanking purine base.

Original languageEnglish
Pages (from-to)1432-1438
Number of pages7
JournalJournal of Physical Chemistry Letters
Volume2
Issue number12
DOIs
Publication statusPublished - Jun 16 2011

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purines
Thymine
thymine
Nucleotides
Ground state
nucleotides
Dimerization
Quantum yield
Excited states
Dimers
ground state
dimerization
adducts
selectivity
dimers
decay
products
electronics
excitation
purine

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Conformational control of thymine photodimerization in purine-containing trinucleotides. / Pan, Zhengzheng; McCullagh, Martin; Schatz, George C; Lewis, Frederick D.

In: Journal of Physical Chemistry Letters, Vol. 2, No. 12, 16.06.2011, p. 1432-1438.

Research output: Contribution to journalArticle

Pan, Zhengzheng ; McCullagh, Martin ; Schatz, George C ; Lewis, Frederick D. / Conformational control of thymine photodimerization in purine-containing trinucleotides. In: Journal of Physical Chemistry Letters. 2011 ; Vol. 2, No. 12. pp. 1432-1438.
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