Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps

Mahesh Hariharan, Martin McCullagh, George C Schatz, Frederick D. Lewis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.

Original languageEnglish
Pages (from-to)12856-12858
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number37
DOIs
Publication statusPublished - Sep 22 2010

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Thymine
Nucleic acids
DNA
Quantum yield
Ground state
Conformations
Theoretical Models
locked nucleic acid

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps. / Hariharan, Mahesh; McCullagh, Martin; Schatz, George C; Lewis, Frederick D.

In: Journal of the American Chemical Society, Vol. 132, No. 37, 22.09.2010, p. 12856-12858.

Research output: Contribution to journalArticle

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