Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps

Mahesh Hariharan, Martin McCullagh, George C. Schatz, Frederick D. Lewis

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23 Citations (Scopus)


The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.

Original languageEnglish
Pages (from-to)12856-12858
Number of pages3
JournalJournal of the American Chemical Society
Issue number37
Publication statusPublished - Sep 22 2010


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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