Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials

Teddy Asefa, Amy N. Otuonye, Gang Wang, Elizabeth A. Blair, Rajyalakshmi Vathyam, Kelley Denton

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of mesoporous nanosphere materials that are functionalized with various terminal and bridging organic groups were synthesized. They have improved adsorption capacity and different release properties for drug and small molecules. The materials contained terminal vinyl, 3-mercaptopropyl, 3-aminopropyl, and secondary amine functional groups and bridging ethane, ethene, and benzene groups within their mesopore channel walls. The samples containing mercaptopropyl and vinyl groups showed greater adsorption capacity and better controlled release behavior for rhodamine 6G molecules. On the other hand, mesoporous matrices containing amine functional groups showed higher adsorption capacity and better release properties for ibuprofen molecules. Further studies revealed that the bridging organic groups in the mesopore channel walls also improved the adsorption capacity and release properties of the materials compared to the corresponding samples containing no bridging organic groups. Such improved adsorption and controlled release properties of molecules by simple changes of functional groups on mesoporous materials are important for the development of nanomaterial drug delivery vehicles and for controlled release of drugs over long time periods at specific targeted sites in the body. By judicious choice of organic groups and by systematic design and synthetic approaches, nanoporous materials having different adsorption capacity and release properties for many other drug molecules can also be achieved.

Original languageEnglish
Pages (from-to)287-299
Number of pages13
JournalAdsorption
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Mesoporous materials
drugs
Adsorption
Molecules
adsorption
Pharmaceutical Preparations
Functional groups
molecules
Amines
Ethane
Nanospheres
Ibuprofen
amines
Benzene
Drug delivery
Nanostructured materials
rhodamine
ethane
delivery
vehicles

Keywords

  • Controlled drug release
  • Drug delivery
  • Multifunctional mesoporous materials
  • Organofunctional mesoporous materials
  • Periodic mesoporous organosilica

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Surfaces and Interfaces
  • Chemistry(all)

Cite this

Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials. / Asefa, Teddy; Otuonye, Amy N.; Wang, Gang; Blair, Elizabeth A.; Vathyam, Rajyalakshmi; Denton, Kelley.

In: Adsorption, Vol. 15, No. 3, 06.2009, p. 287-299.

Research output: Contribution to journalArticle

Asefa, Teddy ; Otuonye, Amy N. ; Wang, Gang ; Blair, Elizabeth A. ; Vathyam, Rajyalakshmi ; Denton, Kelley. / Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials. In: Adsorption. 2009 ; Vol. 15, No. 3. pp. 287-299.
@article{7a510f3ded634cafb3ee6a8b898c4152,
title = "Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials",
abstract = "A series of mesoporous nanosphere materials that are functionalized with various terminal and bridging organic groups were synthesized. They have improved adsorption capacity and different release properties for drug and small molecules. The materials contained terminal vinyl, 3-mercaptopropyl, 3-aminopropyl, and secondary amine functional groups and bridging ethane, ethene, and benzene groups within their mesopore channel walls. The samples containing mercaptopropyl and vinyl groups showed greater adsorption capacity and better controlled release behavior for rhodamine 6G molecules. On the other hand, mesoporous matrices containing amine functional groups showed higher adsorption capacity and better release properties for ibuprofen molecules. Further studies revealed that the bridging organic groups in the mesopore channel walls also improved the adsorption capacity and release properties of the materials compared to the corresponding samples containing no bridging organic groups. Such improved adsorption and controlled release properties of molecules by simple changes of functional groups on mesoporous materials are important for the development of nanomaterial drug delivery vehicles and for controlled release of drugs over long time periods at specific targeted sites in the body. By judicious choice of organic groups and by systematic design and synthetic approaches, nanoporous materials having different adsorption capacity and release properties for many other drug molecules can also be achieved.",
keywords = "Controlled drug release, Drug delivery, Multifunctional mesoporous materials, Organofunctional mesoporous materials, Periodic mesoporous organosilica",
author = "Teddy Asefa and Otuonye, {Amy N.} and Gang Wang and Blair, {Elizabeth A.} and Rajyalakshmi Vathyam and Kelley Denton",
year = "2009",
month = "6",
doi = "10.1007/s10450-009-9176-7",
language = "English",
volume = "15",
pages = "287--299",
journal = "Adsorption",
issn = "0929-5607",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials

AU - Asefa, Teddy

AU - Otuonye, Amy N.

AU - Wang, Gang

AU - Blair, Elizabeth A.

AU - Vathyam, Rajyalakshmi

AU - Denton, Kelley

PY - 2009/6

Y1 - 2009/6

N2 - A series of mesoporous nanosphere materials that are functionalized with various terminal and bridging organic groups were synthesized. They have improved adsorption capacity and different release properties for drug and small molecules. The materials contained terminal vinyl, 3-mercaptopropyl, 3-aminopropyl, and secondary amine functional groups and bridging ethane, ethene, and benzene groups within their mesopore channel walls. The samples containing mercaptopropyl and vinyl groups showed greater adsorption capacity and better controlled release behavior for rhodamine 6G molecules. On the other hand, mesoporous matrices containing amine functional groups showed higher adsorption capacity and better release properties for ibuprofen molecules. Further studies revealed that the bridging organic groups in the mesopore channel walls also improved the adsorption capacity and release properties of the materials compared to the corresponding samples containing no bridging organic groups. Such improved adsorption and controlled release properties of molecules by simple changes of functional groups on mesoporous materials are important for the development of nanomaterial drug delivery vehicles and for controlled release of drugs over long time periods at specific targeted sites in the body. By judicious choice of organic groups and by systematic design and synthetic approaches, nanoporous materials having different adsorption capacity and release properties for many other drug molecules can also be achieved.

AB - A series of mesoporous nanosphere materials that are functionalized with various terminal and bridging organic groups were synthesized. They have improved adsorption capacity and different release properties for drug and small molecules. The materials contained terminal vinyl, 3-mercaptopropyl, 3-aminopropyl, and secondary amine functional groups and bridging ethane, ethene, and benzene groups within their mesopore channel walls. The samples containing mercaptopropyl and vinyl groups showed greater adsorption capacity and better controlled release behavior for rhodamine 6G molecules. On the other hand, mesoporous matrices containing amine functional groups showed higher adsorption capacity and better release properties for ibuprofen molecules. Further studies revealed that the bridging organic groups in the mesopore channel walls also improved the adsorption capacity and release properties of the materials compared to the corresponding samples containing no bridging organic groups. Such improved adsorption and controlled release properties of molecules by simple changes of functional groups on mesoporous materials are important for the development of nanomaterial drug delivery vehicles and for controlled release of drugs over long time periods at specific targeted sites in the body. By judicious choice of organic groups and by systematic design and synthetic approaches, nanoporous materials having different adsorption capacity and release properties for many other drug molecules can also be achieved.

KW - Controlled drug release

KW - Drug delivery

KW - Multifunctional mesoporous materials

KW - Organofunctional mesoporous materials

KW - Periodic mesoporous organosilica

UR - http://www.scopus.com/inward/record.url?scp=67349103405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349103405&partnerID=8YFLogxK

U2 - 10.1007/s10450-009-9176-7

DO - 10.1007/s10450-009-9176-7

M3 - Article

AN - SCOPUS:67349103405

VL - 15

SP - 287

EP - 299

JO - Adsorption

JF - Adsorption

SN - 0929-5607

IS - 3

ER -