Abstract
A facile and reproducible route that can lead to two-dimensional arrays of nanopores in thin polymer films is demonstrated. The formation of the pores in the polymer films involves breath figure phenomenon and occurs during the film deposition by spin coating. The formation of nanoporous thin films takes only few seconds, and the method does not require complex equipment or expensive chemicals. This method also constitutes a straightforward approach to control the size of the pores formed in thin films. Besides allowing control over the average pore size of the porous films, the use of dynamic deposition with the breath figure phenomenon causes the reduction in the pore size to nanometer scale. The nanoporous arrays obtained by the breath figure are applied as substrates for cell growth, and the effect of their nanopore size on cell growth was evaluated. Notably, it is found that cell viability is related to pore size, where 2D nanoporous structure is more beneficial for cell culture than 2D microporous structures. The change in the average pore size of the polymer films from 1.22 μm to 346 nm results in a threefold increase in cell viability.
| Original language | English |
|---|---|
| Pages (from-to) | 150-161 |
| Number of pages | 12 |
| Journal | Journal of Colloid and Interface Science |
| Volume | 466 |
| DOIs | |
| Publication status | Published - Mar 15 2016 |
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Keywords
- Breath figure method
- Cell growth
- Nanofabrication
- Nanopore arrays
- Polystyrene
ASJC Scopus subject areas
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Colloid and Surface Chemistry
Cite this
Controlling cell growth with tailorable 2D nanoholes arrays. / Fragal, Vanessa H.; Cellet, Thelma Sley P; Fragal, Elizângela H.; Pereira, Guilherme M.; Garcia, Francielle P.; Nakamura, Celso V.; Asefa, Teddy; Rubira, Adley F.; Silva, Rafael.
In: Journal of Colloid and Interface Science, Vol. 466, 15.03.2016, p. 150-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Controlling cell growth with tailorable 2D nanoholes arrays
AU - Fragal, Vanessa H.
AU - Cellet, Thelma Sley P
AU - Fragal, Elizângela H.
AU - Pereira, Guilherme M.
AU - Garcia, Francielle P.
AU - Nakamura, Celso V.
AU - Asefa, Teddy
AU - Rubira, Adley F.
AU - Silva, Rafael
PY - 2016/3/15
Y1 - 2016/3/15
N2 - A facile and reproducible route that can lead to two-dimensional arrays of nanopores in thin polymer films is demonstrated. The formation of the pores in the polymer films involves breath figure phenomenon and occurs during the film deposition by spin coating. The formation of nanoporous thin films takes only few seconds, and the method does not require complex equipment or expensive chemicals. This method also constitutes a straightforward approach to control the size of the pores formed in thin films. Besides allowing control over the average pore size of the porous films, the use of dynamic deposition with the breath figure phenomenon causes the reduction in the pore size to nanometer scale. The nanoporous arrays obtained by the breath figure are applied as substrates for cell growth, and the effect of their nanopore size on cell growth was evaluated. Notably, it is found that cell viability is related to pore size, where 2D nanoporous structure is more beneficial for cell culture than 2D microporous structures. The change in the average pore size of the polymer films from 1.22 μm to 346 nm results in a threefold increase in cell viability.
AB - A facile and reproducible route that can lead to two-dimensional arrays of nanopores in thin polymer films is demonstrated. The formation of the pores in the polymer films involves breath figure phenomenon and occurs during the film deposition by spin coating. The formation of nanoporous thin films takes only few seconds, and the method does not require complex equipment or expensive chemicals. This method also constitutes a straightforward approach to control the size of the pores formed in thin films. Besides allowing control over the average pore size of the porous films, the use of dynamic deposition with the breath figure phenomenon causes the reduction in the pore size to nanometer scale. The nanoporous arrays obtained by the breath figure are applied as substrates for cell growth, and the effect of their nanopore size on cell growth was evaluated. Notably, it is found that cell viability is related to pore size, where 2D nanoporous structure is more beneficial for cell culture than 2D microporous structures. The change in the average pore size of the polymer films from 1.22 μm to 346 nm results in a threefold increase in cell viability.
KW - Breath figure method
KW - Cell growth
KW - Nanofabrication
KW - Nanopore arrays
KW - Polystyrene
UR - http://www.scopus.com/inward/record.url?scp=84951172227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951172227&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2015.12.016
DO - 10.1016/j.jcis.2015.12.016
M3 - Article
VL - 466
SP - 150
EP - 161
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
ER -